Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-08-26
1997-06-17
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530331, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
056397291
ABSTRACT:
Tripeptides capable of regulating the function of cells of the mammalian immune and/or central nervous system, pharmaceutical compositions containing the peptides and methods of use thereof are provided.
REFERENCES:
patent: 4190646 (1980-02-01), Goldstein et al.
patent: 4505853 (1985-03-01), Goldstein et al.
patent: 4629723 (1986-12-01), Goldstein et al.
patent: 5013723 (1991-05-01), Sisto et al.
patent: 5028592 (1991-07-01), Lipton
Websters II Dictionary p. 1230.
R. Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Amer. Chem. Soc., 85:2149-2154 (Jul. 20, 1963).
T. Wieland, "Solution vs. Solid-Phase Methods in Peptide Chemistry", in Techniques in protein Chemistry, pp. 59-80, by Academic Press, Inc., New York (1978).
T. Audhya et al, "Isolation and Complete Amino Acid Sequence of Human Thymopoetin and Splenin", Proc. Natl. Acad. Sci. USA, 84:3545-3549 (1987).
G. Heavner et al, "Peptide Analogs of Thymopentin Distinguish Distinct Thymopoietin Receptor Specificities on Two Human T Cell Lines", Regulatory Peptides, 27:257-262 (1990) [Heavner I].
G. Chipens et al, "Localization and Steric Structure of Active Sites and Fragments of Ig Molecules", in LPSR Zinatnu Akademija, (198 ) [Chipens I].
G. Chipens et al, "Synthesis of Immunoproteins: New Biologically Active Low-Molecular Weight Fragments of Immunoglobulins", Bioorganicheskaya Kimiya, 11(4):437-446 (1985) [Chipens II].
G. Heavner et al, "Biologically Active Analogs of Thymopentin with Enhanced Enzymatic Stability", Peptides, 7:1015-1019 (1986) [Heavner II].
R. H. Brown et al, "Immunoreactive Thymopoietin in the Mouse Central Nervous System", Brain Research, 381:237-243 (1986).
K. Venkatasubramanian et al, "Binding of Thymopoietin to the Acetylcholine Receptor", Proc. Natl. Acad. Sci. USA, 83:3171-3174 (1986).
M. Quik et al, "Evidence for Thymopoietin and Thymopoietin/ .alpha.-Bungarotoxin/Nicotinic Receptors within the Brain", Proc. Natl. Acad. Sci. USA, 88:2603-2607 (1991) [Quik I].
M. Quik et al, "Thymopoietin and Thymic Polypeptide, Specifically Interacts at Neuronal Nicotinic .alpha.-Bungarotoxin Receptors", J. Neurochem., 53(4):1320-1323 (1989) [Quik II].
F. Revah et al, "Calcium-Dependent Effect of the Thymic Polypeptide Thymopoietin on the Desensitization of the Nicotinic Acetylcholine Receptor" Proc. Natl. Acad Sci USA, 84:3477-3481 (1987).
M. Quik et al, "Thymopoietin Inhibits Function and Ligand Binding to Nicotinic Receptors at the Neuromuscular Junction", J. Pharm. and Exp. Therap., 254(3):1113-1119 (1990) [Quik III].
M. Weksler et al, "Immunological Studies of Aging IV. The Contribution of Thymic Involution to the Immune Deficiencies of Aging Mice and Reversal with Thymopoietin", J. Exp. Med., 148: 996-1006 (1978).
E. Sundal et al, "Therapy with Thymopentin: A Clinical Overview", Immune Regulation by Characterized Polypeptides, pp. 121-136 (1987).
Merrifield, "Solid Phase Synthesis", Angew. Chem. Int. (ed. Engl.), 24:799-892.
Rajnavogyi et al, "The Influence of New Thymopoietin Derivatives in the Immune Response of Inbred Mice", Chem. Abst., 105:74, Abstract No. 105:800X (1986).
Kassai Tanczos et al, "Submolecular Acid-Base Properties of Bioligands. III. Microspeciation of Thymopoietin-type Tetrapeptides and their Derivatives", Chem. Abst., 115:1053, Abstract No. 136769h (1991).
B. Noszal et al, "Acid-Base Properties of Thymopoietin-type Tri- and Tetrapeptides and their Derivatives", Chem. Abst., 115\:992, Abstract No. 183935u (1991).
H. Kalbacher et al, "Acid Labile Protection of Histidine and Arginine in SPPS using Adpoc Derivatives", Chem. Abst., 115:1079, Abstract No. 208510s (1991).
V. Klusa et al, "Thymopentin Antagonizes Stress-Induced Changes of GABA/Benzodiazepine Receptor Complex", Regulatory Peptides, 27:355-365 (1990).
G. Chipens et al, "Localization and Steric Structure of Active Sites and Fragments of Ig Molecules", in LPSR Zinatnu Akademija (1984) [Chipens I].
A. Costa et al, "Effects of Etoperidone on Sympathetic and Pituitary-Adrenal Responses to Diverse Stressors in Humans", Clin. Neuropharm., 16(2):127-138 (1993).
E. Merlo-Pich et al, "Blockade of Pituitary-Adrenal Axis Activation Induced by Peripheral Immunoneutralization of Corticotropin-Releasing Factor does not Affect the Behavioral Response to Social Defeat Stress in Rats", Psychoneuroendocrinology, 18(7):495-507 (1993).
S Pellow et al, "Validation of Open:Closed Arm Entries in an Elevated Plus-Maze as a Measure of Anxiety in the Rat", J. Neurosci. Meth., 14:149-167 (1985) [Pellow I].
S. Pellow et al, "Anxiolytic and Anxiogenic Drug Effects on Exploratory Activity in an Elevated Plus-Maze: a Novel Test of Anxiety in the Rat", Pharmacol. Biochem. Behavior, 24:525-529 (1986) [Pellow II].
D. Ramsay, "Effects of Circulating Angiotensin II on the Brain", Frontiers in Neuroendocrinology, 7:263-285 (1982).
Goldstein Gideon
Koenig James I.
Shenbagamurthi Ponniah
Chan Christina Y.
Davenport A. M.
Immunobiology Research Institute, Inc.
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