Tripeptide of FcγRIIA

Details Tripeptide of FcγRIIA Tripeptide of FcγRIIA

2006-08-08

2006-08-08

Zeman, Robert A. (Department: 1645)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S023500, C435S069100, C435S455000, C435S458000

Reexamination Certificate

active

07087585

ABSTRACT:
The present invention relates, in general, to phagocytosis and phagolysosomal fusion and, in particular, to a tripeptide of FcγRIIA that mediates trafficking of targets phagocytosed via FcγRIIA to the lysosomal compartment.

REFERENCES:
patent: 5776910 (1998-07-01), Schreiber et al.
patent: 6068983 (2000-05-01), Schreiber et al.
patent: WO 95/09002 (1995-04-01), None
Worth et al, “The cytoplasmic domain of FcgammaRIIA (CD32) participates in phagolysosome formation”, Blood 98(12):3429-3434 (2001)—Abstract.
Downey et al, “Phagosomal Maturation, Acidification, and Inhibition of Bacterial Growth in Nonphagocytic Cells Transfected with FcγRIIA Receptors”, The Journal of Biological Chemistry 274(40):28436-28444 (1999).
Ortalo-Magné et al, “Identification of the Surface-Exposed Lipids on the Cell Envelopes ofMycobacterium tuberculosisand Other Mycobacterial Species”, Journal of Bacteriology 178(2):456-461 (1996).
Mitchell et al, “Substitutions and Deletions in the Cytoplasmic Domain of the Phagocytic Receptor FcγRIIA; Effect on Receptor Tyrosine Phosphorylation and Phagocytosis”, Blood 84(6):1753-1759 (1994).

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