Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1991-08-16
1996-04-16
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
A61K 3800, C07K 508, C07K 500
Patent
active
055083854
ABSTRACT:
Novel tripeptide derivatives having a pyroglutamic acid residue strongly inhibit a plurality of trypsin-like serine proteases such as plasmin, thrombin, trypsin, kallikrein, factor Xa and urokinase. The compounds of the present invention can inhibit various trypsin-like serine proteases and are expected to show remarkable effects as novel protease inhibitors for the treatment of pancreatitis, inflammantion, ulcer, etc.
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patent: 4401594 (1983-08-01), Umezawa et al.
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Chemical Abstracts, vol. 115 (13), 126794n.
Aoyagi et al., J. Antibiotics (Tokyo) 22:283-286 (1969).
Taisha, vol. 14, pp. 1087-1098 (1977).
Bajusz, Symposia Biologica Hungarica 25:277-298 (1984).
Saino et al., J. Antibiotics, 41:220-225 (1988).
Abe Yoshihito
Kuroiwa Katsumasa
Nagasawa Takeshi
Yaginuma Katsuhiro
Chan Christina Y.
Marshall S. G.
Nitto Boseki Co. Ltd.
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