Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1982-09-15
1984-10-30
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 4, 435 23, 435 24, 435 29, 435212, 435214, 435217, 435810, 424101, 424177, 424180, 424183, 436 16, 436 18, 436 69, 436 86, 436 89, C12Q 136, C12Q 138, C12Q 156, C12Q 100
Patent
active
044800304
ABSTRACT:
A process for quantitatively assaying factor Xa from a medium by reacting the medium with tripeptide derivatives having the formula ##STR1## wherein R.sup.5 is a chromogenic substituted amino group capable of being split off by enzymatic hydrolysis to form a colored or fluorescent product H--R.sup.5. The quantity of split product H--R.sup.5 released by the enzymatic action on the tripeptide derivative is determined photometrically, spectrophotometrically, fluorescence-spectrophotometrically, or electrochemically. The quantity of released split product H--R.sup.5 per time unit is proportional to the quantity of enzyme present in the starting material.
REFERENCES:
patent: 4061625 (1977-12-01), Af Ekenstam et al.
patent: 4070245 (1978-01-01), Svendsen
patent: 4137225 (1979-01-01), Af Ekenstam et al.
patent: 4139415 (1979-02-01), Yin et al.
patent: 4190574 (1980-02-01), Svendsen
patent: 4207232 (1980-06-01), Claeson et al.
patent: 4214049 (1980-06-01), Af Ekenstam et al.
patent: 4229540 (1980-10-01), Coan
patent: 4275153 (1981-06-01), Gargiulo et al.
patent: 4276375 (1981-06-01), Claeson et al.
patent: 4278762 (1981-06-01), Svendsen
patent: 4279810 (1981-07-01), Claeson et al.
patent: 4335204 (1982-06-01), Claeson et al.
Chemical Abstracts, vol. 94, p. 269, Abstract No. 13653f: Tran, T. H. et al., "Reactivity of a Heredity Abnormal Antithrombin III Fraction in the Inhibition of Thrombin and Factor Xa".
Chemical Abstracts, vol. 92, p. 397, Abstract No. 178178b: Brown, J. E. et al., "The Inhibition of the Intrinsic Generation of Activated Factor X by Heparin and Hirudin".
Chemical Abstracts, vol. 98, p. 317, Abstract No. 158418a: Lijnen, H. R. et al., "Heparin Binding Properties of Human Histidine-Rich Glycoprotein, Mechanism and Role in the Neutralization of Heparin in Plasma".
Chemical Abstracts, vol. 98, p. 317, Abstract No. 158421w: Lijnen, H. R. et al., "Neutralization of Heparin Activity by Binding to Human-Histidine-Rich Glycoprotein".
Chemical Abstracts, vol. 98, p. 354, Abstract No. 86892a: Matsuo, T. et al., "Effect of Protamine on Antithrombin Activity of Heparinized Plasma".
Chen, A. L. et al., "One-Stage Assay of Heparin", J. Lab. Clin. Med., May 1975, pp. 843-854.
Gomperts, E. D. et al., "The Monitoring of Heparin Activity During Extracorporeal Circulation", S. Afr. Med. J., vol. 51, pp. 973-976, (1977).
Czapek, E. E. et al., "The Effect of a Sulfated Polysaccharide on Antithrombin III", J. Lab. Clin. Med., vol. 95(6), pp. 783-790, (1980).
Goodnight, S. H. et al., "Measurement of Antithrombin III on Normal and Pathologic States Using Chromogenic Substrate S-2238", Amer. Soc. of Clin. Path., vol. 73(5), pp. 639-647, (1980).
Elodi, S. et al., "Activation of Clotting Factors in Prothrombin Complex Concentrates as Demonstrated by Clotting Assays for Factors IXa and Xa", Thrombosis Research, vol. 12(5), pp. 797-807, (1978).
Shuman, M. A. et al., "The Measurement of Thrombin in Clotting Blood by Radioimmunoassay", Journ. of Clin. Invest., vol. 58, pp. 1249-1258, (1976).
Walker, F. J. et al., "The Molecular Mechanisms of Heparin Action: II, Separation of Functionally Different Heparins by Affinity Chromatography", Thrombosis Research, vol. 14, pp. 219-230, (1979).
Seegers, W. H., "Antithrombin III, Theory and Clinical Applications", Amer. Soc. of Clin. Path., vol. 69(4), pp. 367-374, (1978).
Meuleman, D. G. et al., "A Novel Anti-Thrombotic Heparinoid (ORG 10172) Devoid of Bleeding Inducing Capacity: A Survey of its Pharmacological Properties in Experimental Animal Models", Thrombosis Research, vol. 27, pp. 353-363, (1982).
Murphy, T. L. et al., "Endogenous Anticoagulation During Extracorporeal Perfusion: Generation of a Heparinlike Inhibitor", Amer. Path. Soc., (1980), pp. H742-H750.
McDonald, M. M. et al., "Biochemical and Functional Study of Antithrombin III in Newborn Infants", Thromb. Haemostas, vol. 47(1), pp. 56-58, (1982).
Grossman Deborah A.
Pentapharm A.G.
Wiseman Thomas G.
LandOfFree
Tripeptide derivatives and their application in assaying enzymes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tripeptide derivatives and their application in assaying enzymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tripeptide derivatives and their application in assaying enzymes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1102502