Tripeptide derivatives and protease inhibitor composition compri

Details Tripeptide derivatives and protease inhibitor composition compri Tripeptide derivatives and protease inhibitor composition compri

1991-07-30

1992-10-06

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 930 10, A61K 3700, C07K 500

Patent

active

051531763

ABSTRACT:
Tripeptide derivatives of formula (I) such as N-.epsilon.-(p-tosyl)-D-lysyl-L-prolyl-L-argininal have an activity of inhibiting a plurality of trypsin-like serine proteases, e.g., plasmin, thrombin, trypsin, kallikrein, factor Xa, urokinase, etc. in vivo. The tripeptide derivatives can be expected as novel protease inhibitors due to their remarkable pharmaceutical effects.

REFERENCES:
patent: 4883863 (1989-11-01), Abe et al.
patent: 5047400 (1991-09-01), Vincent et al.
Chou et al., "Prediction of Protein Conformation," Biochemistry, vol. 13, No. 2, 1974.

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