Tripeptide angiotensin converting enzyme inhibitors

Details Tripeptide angiotensin converting enzyme inhibitors Tripeptide angiotensin converting enzyme inhibitors

1979-03-19

1980-08-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

042162092

ABSTRACT:
Compounds of the formula HSCH.sub.2 CHR.sup.1 CO--Pro--R.sup.2 --R.sup.3 --OH in which R.sup.1 is hydrogen or lower alkyl, R.sup.2 is an amino acid residue exclusive of prolyl and R.sup.3 is an amino acid residue exclusive of glutamyl are useful for alleviating angiotensin related hypertension.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
Erdos, Federation Proceedings 36, No. 5 (1977) 1760-1765.
Cushman, et al., Biochemistry 16, No. 25 (1977) 5484-5891.
Biological Abstract 65, p. 60613.
Biological Abstract 66, p. 4592.
Biological Abstract 65, p. 66598.
Biological Abstract 65, p. 28660.
Biological Abstract 63, p. 25801.

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