Chemistry: analytical and immunological testing – Optical result – Including reagent preparation
Reexamination Certificate
2006-04-03
2010-02-02
Gakh, Yelena G (Department: 1797)
Chemistry: analytical and immunological testing
Optical result
Including reagent preparation
C436S151000, C436S183000, C436S524000, C436S525000, C422S082010, C422S082020, C422S082030, C556S133000, C568S061000, C568S062000
Reexamination Certificate
active
07655474
ABSTRACT:
A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.
REFERENCES:
Mirkin et al, A DNA-based method for rationally assembling nanoparticles into macroscopic materials, Nature, vol. 382, p. 607-609 (Aug. 15, 1996).
Alivisatos, et al, Organization of ‘nanocrystal molecules’ using DNA, Nature, vol. 382, p. 609-611 (Aug. 15, 1996).
Snow et al, Size-Induced Metal to Semiconductor Transition in a Stabilized Gold Cluster Ensemble, Chemistry of Material. vol. 10, No. 4, p. 947-949, (Mar. 12, 1998).
Hostetler, et al, Alkanethiolate Gold Cluster Molecules with Core Diameters from 1.5 to 5.2 nm: Core and Monolayer Properties as a Function of Core Size, Langmuir, vol. 14, p. 17-30, (Jan. 6, 1998).
Ancona Mario
Chang Eddie L
Foos Edward E
Jhaveri Sulay
Gakh Yelena G
Karasek John J
Ressing Amy
The United States of America as represented by the Secretary of
Xu Robert
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