Chemistry: analytical and immunological testing – Optical result – Including reagent preparation
Reexamination Certificate
2011-04-26
2011-04-26
Kim, Vickie (Department: 1777)
Chemistry: analytical and immunological testing
Optical result
Including reagent preparation
C436S151000, C436S183000, C436S524000, C436S525000, C422S082010, C422S082020, C422S082030
Reexamination Certificate
active
07932096
ABSTRACT:
A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.
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Ancona Mario
Chang Eddie L
Foos Edward E
Jhaveri Sulay
Kim Vickie
Ressing Amy
Roberts Roy
The United States of America as represented by the Secretary of
Xu Robert
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