Trioxopteridine derivatives suitable as medicament

Details Trioxopteridine derivatives suitable as medicament Trioxopteridine derivatives suitable as medicament

1976-01-20

1977-09-06

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31505

Patent

active

040468933

ABSTRACT:
Trioxopteridine derivatives of the formula ##STR1## , wherein R.sub.1 is a normal alkyl group having 0 to 6 hydroxyl groups and R.sub.2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R.sub.2 --A--COOR.sub.3, wherein R.sub.3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula ##STR2## wherein R.sub.4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.

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