Trioxane dimer compounds having antiproliferative and antitumor

Details Trioxane dimer compounds having antiproliferative and antitumor Trioxane dimer compounds having antiproliferative and antitumor

1996-12-02

1998-11-24

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549220, 5462817, C07D32102

Patent

active

058409254

ABSTRACT:
Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.

REFERENCES:
patent: 5225437 (1993-07-01), Posner et al.
"Rational Design, Synthesis and Mechanistic Studies of Endoperoxides Structurally Related to Artemisinin," dissertation submitted to The Johns Hopkins University, Dasong Wang (1996).
"Extraordinarily Potent Antimalarial Compounds: New, Structurally Simple, Easily Synthesized, Tricyclic 1,2,4-Trioxanes," Gary H. Posner, et al., J. Med. Chem., 35:2459-2467 (1992).
"Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells," J. of Natural Products, 56(6):849-856 (1993).
"Antimalarial Activity of Novel Ring-Contracted Artemisinin Derivatives," B. Venugopalan, et al., J. Med. Chem., 38:1922-1927.
"Antimalarial activity of new ethers and thioethers of dihydroartemisinin," B. Venugopalan, et al., Eur. J. Med. Chem. 30:697-706 (1995).

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