Trioxane dimer compounds having antiproliferative and antitumor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514338, A61K 31335

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active

060049979

ABSTRACT:
Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.

REFERENCES:
patent: 5225437 (1993-07-01), Posner et al.
"Extraordinarily Potent Antimalarial Compounds: New, Structurally Simple, Easily Synthesized, Tricyclic 1,2,4-Trioxanes," Gary H. Posner, et al., J. Med. Chem., 35:2459-2467 (1992).
"Cytotoxicity of Artemisinin-Related Endoperoxides to Ehlrich Ascites Tumor Cells," J. of Natural Products, 56(6):849-856 (1993).
"Antimalarial Activity of Novel Ring-Contracted Artemisinin Derivatives," B. Venugoplalan, et al., J. Med. Chem., 38:1922-1927(1995).
"Antimalarial activity of new ethers and thioethers if dihydroartemisinin," B. Venugopalan, et al., Eur. J. Med. Chem. 30:697-706 (1995).

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