Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-04-15
2008-04-15
Canella, Karen A (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007100, C436S063000, C436S501000
Reexamination Certificate
active
07358042
ABSTRACT:
Disclosed are methods for detecting neoplastic or damaged cells and for detecting multidrug resistance in neoplastic or damaged cells by detecting an increase in the cellular expression of a triosephosphate isomerase (TPI) protein in a multidrug resistant neoplastic or damaged cells as compared to the level of expression of the triosephosphate isomerase protein in a normal cell.
REFERENCES:
patent: 4444744 (1984-04-01), Goldenberg
patent: 4720386 (1988-01-01), McCollester
patent: 5194384 (1993-03-01), Bystryn
patent: 5407653 (1995-04-01), Piwnica-Worms
patent: 5762930 (1998-06-01), Fanger et al.
patent: 5801154 (1998-09-01), Frank et al.
patent: 6338853 (2002-01-01), Bystryn
patent: 6352996 (2002-03-01), Cao et al.
patent: 6406689 (2002-06-01), Falkenberg et al.
patent: 6417336 (2002-07-01), Morishima et al.
patent: 6476193 (2002-11-01), Nandabalan et al.
patent: 6511676 (2003-01-01), Boulikas
patent: 6562347 (2003-05-01), Kwak et al.
patent: 6572856 (2003-06-01), Taylor et al.
patent: 6593087 (2003-07-01), Prichard et al.
patent: 6623923 (2003-09-01), Xu et al.
patent: 6630327 (2003-10-01), Mechetner et al.
patent: 6657048 (2003-12-01), Young et al.
patent: 2002/0061316 (2002-05-01), Srivastava
patent: 2002/0110912 (2002-08-01), Jatinder et al.
patent: 2002/0198139 (2002-12-01), Deutschman et al.
patent: 2003/0012793 (2003-01-01), Srivastava et al.
patent: 2003/0012794 (2003-01-01), Srivastava et al.
patent: 2003/0031661 (2003-02-01), Graner et al.
patent: 2003/0087412 (2003-05-01), Nandabalan et al.
patent: 2003/0157081 (2003-08-01), Bonini et al.
patent: 2003/0165519 (2003-09-01), Srivastava
patent: 2003/0180721 (2003-09-01), Witkin
patent: 2004/0185511 (2004-09-01), Georges et al.
patent: 41 12999 (1992-10-01), None
patent: 0813872 (1997-12-01), None
patent: WO 02/071061 (2002-09-01), None
patent: WO 02/082076 (2002-10-01), None
patent: WO 03/008542 (2003-01-01), None
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan r. Liss, Inc., 1983, New York, p4).
Dermer (Bio/Technology, 1994, 12:320).
Drexler et al (Leukemia and Lymphoma, 1993, 9:1-25).
Zellner et al (Clin. Can. Res., 1998, 4:1797-1802).
Tockman et al. (Cancer Res., 1992, 52:2711s-2718s).
Bichart et al. Cytoskeletion alteration in MCF7R, a multidrug resistant human breast cancer cell line.,Anticancer Res., 1997, pp. 3393-3401, vol. 17.
ESSA et al. Vimentin expression in different types of breast carinorn aimmunohistochemical study,J. Eqypt Soc. Parasitol., 1996, pp. 433-442, vol. 26.
Heidenthal et al. The Binding in Vitro of Modified LDL to the Intermediate Filament Protein Vimentin,Biochemical and Biophysical Research Communications, 2000, pp. 49-53, vol. 267.
Meschini et al. Intracellular P-Glycoprotein Expression is Associated with the Intrinsic Multidrug Resistance Phenotype in Human Colon Adenocarcinoma Cells.Int. J. Cancer, (2000), pp. 615-628, vol. 87.
Thomas et al., Association between Keratin and Vimentin Expression, Malignant Phenotype and Survival in Postmenopausal Breast Cancer Patients, Oct. 1999, pp. 2698-2703, vol. 5.
Dermer, BioTechnology, 1994, 12:320.
Dredxler et al., Leukemia and Lymphoma, 1993, 9:1-25.
Freshney, Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc. 1983, New York, p4.
Tockman et al., Cancer Research, 1992, 52:2711s-2718s.
U.S. Appl. No. 10/737,712, filed Dec. 15, 2003, Georges et al.
U.S. Appl. No. 10/736,889, filed Dec. 15, 2003, Georges et al.
Abou-Jawde et al., An Overview of Targeted Treatments in Cancer, Clinical Therapeutics, vol. 25, No. 8, 2003, pp. 2121-2137.
Alqawi and Georges, The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents, Biochemical and and Biophysical Research Communications 303, 2003, pp. 1135-1141.
Barreto et al., Stress-induced release of HSC70 from human tumors, Cellular Immunology 222, 2003, pp. 97-104.
Cheng et al., Retaining of the Assembly Capability of Vimentin Phosphorylated by Mitogen-Activated Protein Kinase-Activated Protein Kinase-2, Journal of Cellular Biochemistry, 89, 2003, pp. 589-602.
Den Boer et al., Relationship Between Major Vault Protein/Lung Resistance Protein, Multidrug Resistance-Associated Protein, P-Glycoprotein Expression, and Drug Resistance in Childhood Leukemia, Blood, vol. 91, No. 6, 1998, pp. 2092-2098.
Di Pietro et al., Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters, Cell. Mol. Life Sci. 59, 2002, pp. 307-322.
Du et al., Dual Requirement for Rho and Protein Kinase C in Direct Activation of Phospholipase D1 Through G Protein-coupled Receptor Signaling, Molecular Biology of the Cell, vol. 11, 2000, pp. 4359-4368.
Durbin et al., An epitope on carcinoembryonic antigen defined by the clinically relevant antibody PR1A3, Proc. Natl. Acad. Sci. USA, vol. 91, 1994, pp. 4313-4317.
Faigle et al., Vimentin Filaments in Fibroblasts Are a Reservoir for SNAP23, a Component of the Membrane Fusion Machinery, Molecular Biology of the Cell, vol. 11, 2000, pp. 3485-3494.
Feig, Designer Drugs: New Directed Therapies for Cancer, International Journal of Hematology Suppl. II, 76, 2002, pp. 281-283.
Fujita et al., High Molecular Weight Vimentin Complex Is Formed after Proteolytic Digestion of Vimentin by Caspase-3: Detection by Sera of Patients with Interstitial Pneumonia, Microbiol. Immunol., 47(6), 2003, pp. 447-451.
Garnett, Targeted drug conjugates: principles and progress, Advanced Drug Delivery Reviews, 53, 2001, pp. 171-216.
Goto et al., Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK), Genes to Cells, 7, 2002, pp. 91-97.
Gratama et al., Flow Cytometric Quantitation of Immunofluorescence Intensity: Problems and Perspectives, Cytometry 33, 1998, pp. 166-178.
Heidenthal et al., The Binding in Vitro of Modified LDL to the Intermediate Filament Protein Vimentin, Biochemical and Biophysical Research Communications, 267, 2000, pp. 49-53.
Herrmann and AEBI, Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics, Current Opinion in Cell Biology, 12, 2000, pp. 79-90.
Hubert et al., STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors, PNAS, vol. 96, No. 25, 1999, pp. 14523-14528.
Iqbal and Lenz, Targeted Therapy and Pharmacogenomic Programs, Cancer Supplement, vol. 97, No. 8, 2003, pp. 2076-2082.
Kim et al., Multidrug Resistance-Associated Protein (MRP) is expressed in osteosarcoma but is not a significant me[c]hanism of drug resistance, 47th Ann. Mtg., Orthopaedic Research Society, 2001, p. 0855.
Kim, Targeted therapies for the treatment of cancer, The American Journal of Surgery, 186, 2003, pp. 264-268.
Kown et al., In Vivo Imaging of Acute Cardiac Rejection in Human Patients Using 99m Technetium Labeled Annexin V, American Journal of Transplantation, 1, 2001, pp. 270-277.
Kreitman and Pastan, Immunotoxins for targeted cancer therapy, Advanced Drug Delivery Reviews, 31, 1998, pp. 53-88.
Ling, Multidrug resistance: molecular mechanisms and clinical relevance, Cancer Chemother. Pharmacol., 40 Suppl., 1997, pp. S3-S8.
Meschini et al., Intracellular P-glycoprotein expression is associated with the intrinsic multidrug resistance phenotype in human colon adenocarcinoma cells, Int. J. Cancer, 87, 2000, pp. 615-628.
Mor-Vaknin et al., Vimentin is secreted by activated macrophages, Nature Cell Biology, vol. 5, 2003, pp. 59-63.
Park, Tumor-directed Targeting of Liposomes, Bioscience Reports., vol. 22, No. 2, 2002, pp. 267-281.
Patterson et al., Reduced numatrin/B23/Nucleophosmin Labeling in Apoptotic Jurkat T-lymphoblasts, The Journal of Biological Chemistry, vol. 270, No. 16, 1995, pp. 9429-9436.
Rots et al., Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors, Journal of Controlled Release, 87, 2003, pp. 159-165.
Rowlinson-Busza and Epenetos, Targeted delivery of biologic and other antineoplastic agents, Current Opinion in Oncology, 4. 1992, 1142-1148.
Schroeijers et al., the Mr 193,000 Vault Protein Is Up-Regulated in Multidrug-resistant Cance
Bonneau Anne-Marie
Dallaire Frédéric
Georges Elias
Serfass Lucile
Aurelium Biopharma, Inc.
Canella Karen A
Joyce Catherine
Wilmer Cutler Pickering Hale & Dorr LLP
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