Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-03-27
1999-11-30
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4353201, 435325, 536 235, 536 2431, C12N 500, C12N 1500, C07H 2104
Patent
active
059940700
ABSTRACT:
Nucleic acids encoding TRIO proteins, the TRIO proteins themselves, and active portions thereof as described. In addition, antibodies immunoreactive with TRIO proteins, and preparations of such compositions are provided. Diagnostic and therapeutic assays and reagents for detecting and treating disorders involving, for example, aberrant expression (or loss thereof) of the TRIO protein are described. Assays are provided for identifying agents that modulate the biological function of TRIO proteins.
REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Streuli et al., "Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region," EMBO, vol. 11, No. 3, 897-907 (1992).
Serra-Pages et al., "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-integrating protein co-localize at focal adhesions," EMBO, vol. 14, No. 12, 2827-2838 (1995); Copy of Genbank.TM. Search Using Nucleotide Sequence of trio.
CF Bennett (1996) Science 271:434.
K Theiler (1989) The House Mouse pp. 148-149.
JF Milligan et al. (1993) J Med Chem 36: 1923-1937.
MD Adams et al (1993) Nature 355: 632-634.
Debant Anne
Serra-Pages Carles
Streuli Michel
Campell Bruce R.
Dana-Farber Cancer Institute
Mandragouras Amy E.
Williams Megan E.
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