Trimethylsphingosine derivatives

Details Trimethylsphingosine derivatives Trimethylsphingosine derivatives

1996-05-13

2000-02-29

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

514549, 514561, 514642, 514643, 554109, 564282, 564507, A61K 3123, A61K 3120, A61K 3114

Patent

active

060311355

ABSTRACT:
The invention relates to trimethylsphingosine derivatives which have some or all of the activities of the parent compound.

REFERENCES:
patent: 5137919 (1992-08-01), Igarashi et al.
Hannun et al. "Lysosphinzolipids Inhibit Protein Kinase C, etc." Science, vol. 235, (1987) pp. 670-674.
Merrill, Jr, "Structural Requirements For Long Chain (Sphinzoid) Base Inhibition" Biochemistry (1989), 28, 3138-3145.
Endo et al., "Cell Membrane Signaling as Target in Cancer Therapy, etc." Cancer Research (1991), 51, pp. 1613-1618.

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