Trimethyl siloxane steroid intermediates

Details Trimethyl siloxane steroid intermediates Trimethyl siloxane steroid intermediates

1975-10-28

1977-07-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, C07J 7100

Patent

active

040368319

ABSTRACT:
A procedure for converting steroids characterized by presence of an 11.beta.OH group into potent corticoids having one or more substituents, such as 6.alpha.F, 16.alpha., 17.alpha.-hydroxy or isopropylidene dioxy, 16.alpha. or 16.beta. methyl, .DELTA..sup.1,4 ; by reacting the 11.beta.-hydroxy steroid with trichloromethyl siloxane steroid, thereby rendering the normally sensitive 11 substituent inert to the series of reactions which thereafter incorporate one or more of the desired above listed substituents into the steroid molecule. The siloxy group is then hydrolyzed to regenerate the 11.beta.-hydroxy substituent.
Many of the trimethyl siloxy steroids are novel compounds.
The siloxane may be selectively cleaved by reaction of the finely divided steroid with 40-60% aqueous HF.

REFERENCES:
patent: 2798118 (1957-04-01), Bernstein et al.
patent: 2841600 (1958-07-01), Hogg et al.
Chem. Abstracts vol. 68, 1968 pars. 69,177j, relied on.
Merck Index (1960) p. 462, relied on.

Affiliated with

Also associated with

Rating

Trimethyl siloxane steroid intermediates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trimethyl siloxane steroid intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trimethyl siloxane steroid intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2292535