Trihalomethionine derivative and pharmaceutical product...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C564S198000, C514S626000

Reexamination Certificate

active

07868206

ABSTRACT:
A compound represented by the formula (I) is used as an active ingredient in a medicament for treatment or prevention of infectious diseases caused by protozoa or bacterium.X represents halogen, Z represents —(CH2)m— wherein m is an integer of 1-5, and R represents one of the following (i)-(v):(i) hydrogenn represents an integer of 0-5, R1's independently represent hydrogen, halogen, alkoxy having 1-5 carbon atoms or alkyl having 1-5 carbon atoms.R2's independently represent hydrogen, halogen, alkoxy having 1-5 carbon atoms or alkyl having 1-5 carbon atoms.(iv) alkyl having 1-5 carbon atoms,(v) hydroxyalkyl having 1-5 carbon atoms.

REFERENCES:
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patent: 2003-522815 (2003-07-01), None
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patent: WO 2004/078349 (2004-09-01), None
RN 143673-85-2, 1992.
Houston Jr., et al. “Syntheses of and Chemotactic Responses Elicited by fMET-LEU-PHE Analogs Containing Difluoro- and Trifluoromethionine,”Bioorganic&Medicinal Chemistry Letters, vol. 7, No. 23, pp. 3007-3012, 1997.
Seko, et al. “Structure—Activity Study of L-Amino Acid-Based N-Type Calcium Channel Blockers,”Bioorganic&Medicinal Chemistry, vol. 11, pp. 1901-1913, 2003.
International Search Report dated Mar. 6, 2007.

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