Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1999-05-25
2000-07-04
Carr, Deborah D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514532, 514547, 514549, 514552, 514558, 514814, 514815, 514885, 554218, 554219, 554220, 554227, 560 8, 560 76, A01N 3710
Patent
active
060839848
ABSTRACT:
Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain .beta.-hemoglobinopathies, anemia, and cancer.
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Walsh et al., The Journal of Biological Chemistry, vol. 265, no. 8, pp. 4374-4381 (1990), sn-1,2-Diacylgylcerol Kinase of Escherichia coli.
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Acdemie Des Sciences., Chimie Organique, "Preparation de quelques glycerides phenylaliphatiques et leur reduction en alcools . . . ", pgs. 682-684, 1937.
Brusilow et al., Metabolism, vol. 42, No. 10 Oct., 1993, pp. 1336-1339, "Restoration of Nitrogen Homeostasis in a Man with Ornithine Transcarbamylase Deficiency".
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Georges Darzens et al.: "Preparation de quelques glycerides phenylaliphatiques et leur reduction en alcools . . . ", Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences., vol. 205, Oct. 18, 1937, pgs. 682-684.
Brusilow Enterprises LLC
Carr Deborah D.
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