Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2007-09-25
2007-09-25
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
10441781
ABSTRACT:
Methods and compositions for triggering the delivery of an encapsulated therapeutic agent from a liposome are provided. Liposomes of opposite charge and incorporating lipids which favor non-lamellar structures are contacted in vivo. At least one of the liposome encapsulates at least one therapeutic drug or agent. Preferably, the liposomes have a fusogenic hydrophillic coating, such as PEG to control the rate of interaction of the liposomes and release of the therapeutic agent.
REFERENCES:
patent: 4186183 (1980-01-01), Steck et al.
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4261975 (1981-04-01), Fullerton et al.
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774085 (1988-09-01), Fidler
patent: 4837028 (1989-06-01), Allen
patent: 4885172 (1989-12-01), Bally et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4957773 (1990-09-01), Spencer et al.
patent: 5023087 (1991-06-01), Yau-Young
patent: 5059421 (1991-10-01), Lougrey et al.
patent: 5077056 (1991-12-01), Bally et al.
patent: 5171578 (1992-12-01), Bally et al.
patent: 5208036 (1993-05-01), Eppstein et al.
patent: 5279833 (1994-01-01), Rose
patent: 5532152 (1996-07-01), Cousens et al.
patent: 5736155 (1998-04-01), Bally et al.
patent: 5753613 (1998-05-01), Ansell et al.
patent: 5820873 (1998-10-01), Choi et al.
patent: 5837282 (1998-11-01), Fenske et al.
patent: 5885613 (1999-03-01), Holland et al.
patent: 6320017 (2001-11-01), Ansell
patent: WO91/17424 (1991-11-01), None
Bailey, A. et al., “Membrane Fusion with Cationic Liposomes: Effects of Target Membrane Lipid Composition,”Biochemistry 36(7):1628-1634, Feb. 1997.
Bloomfield, V., “Quasi-Elastic Light Scattering Application in Biochemistry and Biology,”Ann. Rev. Biophys. Bioeng. 10:421-450, 1981.
Burnell, E. et al., “Effects of Tumbling and Lateral Diffusion on Phosphatidylcholine Model Membrane31P-NMR Lineshapes,”Biochim Biophys Acta 603(1):63-69, Dec. 1980.
Cullis, P. et al., Polymorphic Phase Behaviour of Lipid Mixtures as detected by31P NMR. Evidence that Cholesterol may Destabilize Bilayer Structure in Membrane Systems Containing Phosphatidylethanolamine,Biochim. Biophys Acta 507(2):207-218, Feb. 1978.
Cullis, P. et al., “The Polymorphic Phase Behaviour Of Phosphatidylethanolamines of Natural and Synthetic Origin. A31P NMR Study,”Biochim Biophys Acta 513(1):31-42, Oct. 1978.
Cullis, P. et al., “Polymorphic Phase Behaviour of Cardiolipin as Detected by31P NMR and Freeze-Fracture Techniques. Effects of Calcium, Dibucaine and Chlorpromazine,”Biochim Biophys Acta 513(1):11-20, Oct. 1978.
Cullis, P. et al.,Biochemistry of Lipids, Lipoproteins and Membranes, (Vance et al. ed.), Elsevier, Amsterdam, 1996, Ch. 1, “Physical Properties and Functional Roles of Lipids in Membranes,” pp. 1-33.
Deamer, D. et al., “Large Volume Liposomes by an Ether Vaporization Method,”Biochim Biophys Acta 443:629-634, 1976.
Drummond, D. et al., “Current Status of pH-Sensitive Liposomes in Drug Delivery,”Progress in Lipid Research 39(1):409-460, Sep. 2000.
U.S. Appl. No. 08/316,407, filed Sep. 30, 1994, Holland et al.
U.S. Appl. No. 08/316,394, filed Sep. 30, 1994, Ansell.
U.S. Appl. No. 08/996,783, filed Feb. 2, 1998, Ansell.
U.S. Appl. No. 09/541,436, Sarris et al.
Fiske, C. et al., “The Colorimetric Determination of Phosphorus,”J. Biol. Chem. 66(2):375-400, 1925.
Fraley, R. et al., “Entrapment of a Bacterial Plasmid in Phospholipid Vesicles: Potential for Gene Transfer,”Proc. Natl. Acad. USA 76(7):3348-3352, Jul. 1979.
Gerasimov, O. et al.,Vesicles, (Rosoff ed.), Marcel Dekker, Inc., New York, 1996, “Ch. 17, triggered Release form Liposomes Mediated by Physically and Chemically Induced Phase Transitions,” pp. 679-746.
Hafez, I. et al., “Tunable pH-Sensitive Liposomes Composed of Mixtures of Cationic and Anionic Lipids,”Biophysical Journal 79:1438-1446, Sep. 2000.
Hafez, I. et al., “On the Mechanism whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids,”Gene Therapy 8(15):1188-1196, Aug. 2001.
Haran, G. et al., “Transmembrane Ammonium Sulfate Gradients in Liposomes Produce Efficient and Stable Entrapment of Amphiphatic Weak Bases,”Biochim Biophys Acta 1151(2):201-215, Sep. 1993.
Hayashi, H. et al., “Temperature-Controlled Release Property Of Phospholipid Vesicles Bearing A Thermo-Sensitive Polymer,”Biochim Biophys Acta 1280(1):127-134, Apr. 1996.
Heath, T., “Covalent Attachment of Proteins to Liposomes,”Methods in Enzymology 149:111-119, 1987.
Holland, J. et al., “Poly(ethylene glycol)-Lipid Conjugates Regulate the Calcium-Induced Fusion of Liposomes Composed of Phosphatidylethanolamine and Phophatidylserine,”Biochemistry 35(8):2618-2624, Feb. 1996.
Holland, J. et al., “Poly(ethylene glycol)-Lipid Conjugates Promote Bilayer Formation In Mixtures Of Non-Bilayer-Forming Lipids,”Biochemistry 35(8):2610-2617, Feb. 1996.
Hope, et al., “Ca2+and pH Induced Fusion of Small Unilamellar Vesicles Consisting of Phosphatidylethanolamine and Negatively Charged Phospholipids: A Freeze Fracture Study,”Biochem Biophys Res Commun. 110(1):15-22, Jan. 1983.
Hope, M. et al., “Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure. Characterization of Size Distribution, Trapped Volume and Ability to Maintain a Membrane Potential,”Biochim. et Biophys. Acta 812:55-65, 1985.
Hope et al., “Generation of Multilamellar and Unilamellar Phospholipid Vesicles,”Chem. and Phys. of Lipids 40:89-107, 1986.
Hyde, S. et al., “Correction of the Ion Transport Defect in Cystic Fibrosis Transgenic Mice by Gene Therapy,”Nature 362(6417):250-255, Mar. 1993.
Juliano, R. et al., “The Effect of Particle Size and Charge on the Clearance Rates of Liposomes and Liposome Encapsulated Drugs,”Biochem Biophys Res Commun. 63(3): 651-658, Apr. 1975.
King, R.E.,Remington's Pharmaceutical Sciences, 17thEd., Mack Publishing Co., Philadelphia, PA, 1985, Part 8, “Pharmaceutical Preparations and Their Manufacture,” pp. 1409-1677.
Lai, M-Z. et al., “Acid- and Calcium-Induced Structural Changes in Phosphatidylethanolamine Membranes Stabilized by Cholesteryl Hemisuccinate,”Biochemistry 24(7): 1654-61, Mar. 1985.
Leonetti, J-P. et al., “Antibody-Targeted Liposomes Containing Oligodeoxyribonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication,”Proc. Natl. Acad. Sci. USA 87:2448-2451, Apr. 1990.
Marchi-Artzner, V. et al., “Interaction, Lipid Exchange, and Effect of Vesicle Size in Systems of Oppositely Charged Vesicles,”J. Phys. Chem. 100:13844-13856, 1996.
Mayer, L. et al., “Vesicles of Variable Sizes Produced by a Rapid Extrusion Procedure,”Biochim. et Biophys. Acta 858:161-168, 1986.
Ostre, M.J. (ed.),Liposomes: From Biophysics to Therapeutics, Marcel Dekker, New York, 1993, Chapter 1, “Materials Properties of Liposomal Bilayers,” pp. 1-38.
Pantazatos, D., et al., “Directly Observed Membrane Fusion Between Oppositely Charged Phospholipid Bilayers,”J Membr Biol. 170(1): 27-38, Jul. 1999.
Pick, U., “Liposomes with Large Trapping Capacity Prepared by Freezing and Thawing of Sonicated Phospholipid Mixtures,”Archives of Biochemistry and Biophysics 212(1):186-194, Nov. 1981.
Renk, G. et al., “Analogue Pigment Studies of Chromophore-Protein Interactions in Metarhodopsins,”Biochemistry 28(2):907-912, Nov. 1989.
Renneisen, K. et al., “Inhibition of Expression of Human Immunodeficiency Virus-1 in Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to theenvRegion,”J. Biol. Chem. 265(27):16337-163
Cullis Pieter R.
Maurer Norbert
Wong Kim F.
Zhigaltsev Igor V.
Kishore Gollamudi S.
Seed IP Law Group PLLC
University of British Columbia
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