Triggered release from proteinoid microspheres

Details Triggered release from proteinoid microspheres Triggered release from proteinoid microspheres

2007-07-03

2007-07-03

Nashed, Nashaat T. (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000, C424S491000

Reexamination Certificate

active

10840557

ABSTRACT:
The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the invention may be used to encapsulate a material or a compound and to provide slow, sustained or timed release of the material or compound. The proteinoid microspheres are stable in solution until exposed to a reducing agent. However, the in vivo environment provides a sufficient reduction potential to provide slow, sustained release of materials contained therein from the proteinoid microspheres of the present invention.

REFERENCES:
patent: 4101380 (1978-07-01), Rubinstein et al.
patent: 4925673 (1990-05-01), Steiner et al.
patent: 4954435 (1990-09-01), Krauth
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5399331 (1995-03-01), Loughery et al.
patent: 5437274 (1995-08-01), Khoobehi et al.
patent: 5679377 (1997-10-01), Bernstein et al.
patent: 5834232 (1998-11-01), Bishop et al.
patent: 6180140 (2001-01-01), Leone-Bay et al.
patent: 6191278 (2001-02-01), Lee et al.
patent: 6193953 (2001-02-01), Lohrmann et al.
patent: 6232295 (2001-05-01), Kayyem et al.
patent: 6413550 (2002-07-01), Milstein et al.
patent: 6541606 (2003-04-01), Margolin et al.
patent: 6576263 (2003-06-01), Truong et al.
patent: 6660843 (2003-12-01), Feige et al.
patent: 6902892 (2005-06-01), Salceda et al.
patent: 7056535 (2006-06-01), Quirk
patent: 2003/0118479 (2003-06-01), Quirk et al.
patent: 2003/0138975 (2003-07-01), Quirk
Faulstich, H., et al., 1993, “Derivitization of proteins with a new class of thiol-specific reagents”, Chemistry of Peptides and Proteins, vol. 5, No. 6(PT. B), pp. 581-587.
Faulstich, H., et al., 1993, “Interchain and intrachain crosslinking of actin thiols by a bihunctional thiol-specific reagent”, FEBS Letters, vol. 302, No. 3, pp. 201-205.
Faulstich, H, et al., 1995, “Reversible introduction of thiol compounds into proteins by use of activated mixed disulfides”, Methods in Enzymology,.vol. 251(Biothiols, Part A), pp. 357-366.
Kliche, W., et al., 1999, “Thiol-Specific Cross-Linkers of Variable Length Reveal a Similar Separation of SH1 and SH2 in Myosin Subfragment 1 in the Presence and Absence of MgADP”, Biochemistry, vol. 38, No. 32, pp. 10307-10317.
Green, N. S., et al., 2001, “Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers”, Protein Science, vol. 10, No. 7, pp. 1293-1304.
Junghans, M., “Phosphodiester And Phosphorothioate Oligonucleotide Condensation And Preparation of Antisense Nanoparticles”,Biochimica Et Biophysica Acta., 1544, (Jan. 2001), 177-188.

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