Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-02-03
1996-04-30
Kunz, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 2432, 546106, 548116, 552544, 556405, C07H 2104, C07F 906, C07F 704, C07D21908
Patent
active
055126677
ABSTRACT:
Oligonucleotides having a low molecular weight tail molecules joined to the 3' terminus of the oligonucleotide via a linking molecule of the structure:
REFERENCES:
patent: 5141813 (1992-08-01), Nelson
patent: 5401837 (1995-03-01), Nelson et al.
patent: 5451463 (1995-09-01), Nelson et al.
Stanfield et al. J. Org. Chem. 46: 4799, 1981.
T. Saison-Behmoaras, et al, "Short Modified Antisense Oligonucleotides Directed Against Ha-ras Point Mutation Induce Selective Cleavage of the mRNA and Inhibit T24 Cells Proliferation", the EMBO Journal Vo. 10, No. 5, pp. 1111-1118, 1991.
Frank Seela, et al, "Oligodeoxyribonucleotides Containing 1,3-Propanediol As Nucleoside Substitute", IRL Press Limited, Oxford, England, Nucleic Acids Research, vol. 15, No. 7, 1987.
Robert L. Letsinger, et al., "Cholesteryl-conjugated Oligonucleotides Synthesis: Properties, and Activity as Inhibitors of Republication of Human Immunodeficiency Virus in Cell Culture", Proc, Natl. Acad, Sci, USA, vol. 86, pp. 6553-6556, Sep. 1989, Biochemistry.
Ulysse Asseline, et al., "Nucleic Acid-Binding Molecules with High Affinity and Base Sequence Specificity: Intercalating Agents Covalently Linked to Oligodeoxynucleotides", Proc. Natl. Acad. Sci, U.S.A., vol. 81, pp. 3297-3301, Jun. 1984, Biochemistry.
Paul S. Nelson et al., "Bifunctional Oligonucleotide Probes Synthesized Using a Novel CPG Support Are Able to Detect Single Base Pair Mutations", Nucleic Acids Research, vol. 17, No. 18, 1989, pp. 7187-7194.
J. Synese, et al, Chem. Abst. 106: 213981q, p. 652, vol. 106, 1987.
Michael W. Reed, et al, "Acridine- and Cholesterol- Derivatized Solid Supports for Improved Synthesis of 3'-Modified Oligonucleotides", Bioconjugate Chemistry, No. 2, American Chemical Society, 1991, pp. 217-225.
R. T. Pon et al., "Derivatization of Controlled Pore Glass Beads for Slid Phase Oligonucleotide Synthesis", BioTechniques, 6(8): 768-775 (1988).
T. Atkinson et al., "Solid-Phase Synthesis of Oligodeoxyribonucleotides by the Phosphite-triester Method", Oligonucleotide Synthesis, A. Practical Approach, M. J. Gait, ed. IRL Press, pp. 35-81 (1984).
J. C. Francois et al., "Periodic Cleavage of Poly(dA) by Oligothymidylates Covalently Linked to the 1,10-Phenanthrioline-Copper Complex," Biochemistry 27: 2272-76 (1988).
G. B. Dreyer et al., "Sequence-Specific Cleavage of Single-Stranded DNA: Oligodeoxynucleotide-EDTA.FE(II)," Proc. Natl. Acad. Sci. U.S.A. 82: 968-72 (Feb. 1985).
C. F. Stanfield et al., "Synthesis of Protected Amino Alcohols: A Comparative Study," J. Org. Chem. 46: 4799-4800 (1981).
Meyer, Jr. Rich B.
Reed Michael W.
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