Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-07-17
1997-10-28
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530326, 514 12, 514 13, A61K 3836, A61K 3816, C07K 1400
Patent
active
056819250
ABSTRACT:
Novel compounds which contain a thrombin catalytic-site inhibitor coupled with an anion binding exosite associating moiety via an RGD-X bridging sequence are trifunctional anticoagulants useful in treating venous or arterial thrombotic conditions.
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Broersma, Jr. Robert J.
Krstenansky John L.
Owen Thomas J.
Borin Michael L.
Boudreaux William R.
Merrell Pharmaceuticals Inc.
Tsang Cecilia J.
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