Trifunctional antibody-like compounds as a combined diagnostic a

Details Trifunctional antibody-like compounds as a combined diagnostic a Trifunctional antibody-like compounds as a combined diagnostic a

1991-12-13

1993-12-28

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 11, 424 9, 424 8591, 5303873, 5303882, 53038885, 5303889, 5303915, 5303917, 5303919, 5303897, 5303898, 5303911, 5303913, 435972, 436819, A61K 39395, A61K 3944, A61K 4902, C07K 1528

Patent

active

052737438

ABSTRACT:
The present invention has multiple aspects. In its first aspect the present invention is directed to a trifunctional antibody-like compound that has tissue, organ, cell or molecule specificity and which is capable of being bifunctional when immobilized, via binding, at the tissue, organ, cell or molecule for which it has specificity. In particular, the present invention is directed to a trifunctional antibody-like compound of Formula I:

REFERENCES:
patent: 3927193 (1975-12-01), Hansen et al.
patent: 4433059 (1984-02-01), Chang et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4687732 (1987-08-01), Ward et al.
patent: 4714681 (1987-12-01), Reading et al.
patent: 4722892 (1988-02-01), Meares et al.
patent: 4814438 (1989-03-01), Armour et al.
patent: 4831122 (1989-05-01), Buchsbaum
patent: 4837003 (1989-06-01), Nicolotti et al.
patent: 5091542 (1992-02-01), Ahlem et al.
Liu et al. (1985) PNAS USA 82:8648-8652.
Tutt et al. (1991) J. Immunol 147(1)60-69.
Jung et al. (1991) Eur. J. Immunol. 21:2431-2435.
Glennie et al. (1987) J. Immunol. 139:2367-2375.
Chemical Dictionary fifth edition, Grant et al. McGraw-Hill Book Company, N.Y. etc. 1987 p. 192.
Mashuo et al., "Cytoxicity of a Hybrid Prepared by Coupling Diphtheria Toxin A-chain with N,N'-o-phenylenedimaleimide," Biochem. and Biophys. Res. Comm. 102, 561-567 (1981).
Hashida, et al., "More Useful Maleimide Compounds for the Confugation of Fab' to Horseradish Peroxidase Though Thiol Groups in the Hinge," J. Appl. Biochem., 6, 56-63 (1984).
Hamaguchi, et al., "Improved Procedure for the Conjugation of Rabbit IgG and Fab' antibodies . . . , " J. Biochem, 85, 1289-1300 (1979).
Keller, et al., "Preparation and Some Properties of Maleimide Acids and Maleoyl Derivatives of Peptides," Helv. Chim. Acta, 58 531-541 (1975).
Beidler, et al., "Cloning and High Level Expression of a Chimeric Antibody with Specificity for Human Carcinoembryonic Antigen," J. Immunol., 141, 4053-60 (1988).
Reardan, et al., Antibodies Against Metal Chelates, Nature, 316, 265-268 (1985).
Stevenson et al. (1985a) "Surface Immunoglobulen of B-tumors as a therapeutic target" Cancer Surveys 4(1):213-244.
Stevenson et al. (1985b) "Preparation and properties of FabIg G . . . " Bioscience, Reports 5:992-998.
CA 107(20):176632F.
CA 111(6): 39963b.
Rich et al. (1975) J. Medicinal Chem. 18(10)1004-1010 (See p. 1006).

Affiliated with

Also associated with

Rating

Trifunctional antibody-like compounds as a combined diagnostic a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trifunctional antibody-like compounds as a combined diagnostic a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trifunctional antibody-like compounds as a combined diagnostic a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1541236