Trifluoromethylketone sulfides and reversible enzyme inhibition

Details Trifluoromethylketone sulfides and reversible enzyme inhibition Trifluoromethylketone sulfides and reversible enzyme inhibition

1983-08-18

1985-12-31

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

568 23, 568 25, 568308, C07C15100

Patent

active

045622922

ABSTRACT:
Novel compounds are provided which have the formula ##STR1## where R is a substituent having at least five multivalent atoms. The compounds are reversible inhibitors of hydrolytic enzymes, and offer potential as drug and pesticide synergists and antagonists. Some are extremely potent inhibitors of juvenile hormone esterases. The compounds having the single 1,1,1-trifluoro-3-substituted thiopropan-2-one moiety can be immobilized to solid supports and used as ligands in affinity chromatography.

REFERENCES:
patent: 2834707 (1958-05-01), Smith et al.
patent: 2974086 (1961-03-01), Beroza et al.
patent: 3356566 (1967-12-01), Goodhue et al.
patent: 3389181 (1968-06-01), Merritt
patent: 3689659 (1972-09-01), Langkammerer
patent: 3748361 (1973-07-01), Rosenfeld et al.
patent: 3787443 (1974-01-01), Erickson
patent: 3856750 (1974-12-01), Guillory et al.
patent: 3879429 (1975-04-01), Chodnekar et al.
patent: 3935271 (1976-01-01), Schelling et al.
patent: 3937738 (1976-02-01), Throckmorton
patent: 3944531 (1976-03-01), Chodnekar et al.
patent: 3965190 (1976-06-01), Guidicelli et al.
patent: 4001339 (1977-01-01), Chodnekar et al.
patent: 4020169 (1977-04-01), Remy et al.
patent: 4140794 (1979-02-01), Piccardi et al.
patent: 4172851 (1979-10-01), Childs
patent: 4225619 (1980-09-01), Brickl et al.
patent: 4229470 (1980-10-01), Piccardi et al.
patent: 4243683 (1981-01-01), Broughton et al.
patent: 4322441 (1982-03-01), Engel et al.
patent: 4347256 (1982-08-01), Bowers
patent: 4358308 (1982-11-01), Swithenback
patent: 4371708 (1983-02-01), Kramer et al.
Hammock et al., Pestic. Biochem. Physiol. 17 76-88 (1982).

Affiliated with

Also associated with

Rating

Trifluoromethylketone sulfides and reversible enzyme inhibition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trifluoromethylketone sulfides and reversible enzyme inhibition , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trifluoromethylketone sulfides and reversible enzyme inhibition will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1025643