Trifluoromethylation process

Details Trifluoromethylation process Trifluoromethylation process

1995-01-18

1995-12-12

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570142, 549 29, 548560, 546180, 546346, C07C 2513, C07D21518, C07D21172, C07D20730

Patent

active

054751659

ABSTRACT:
Aryl halide, such as idodobenzene, is reacted with perfluoromethoxycarboxylate, such as CF.sub.3 OCF.sub.2 CO.sub.2 K, in the presence of CuI and an inert aprotic polar solvent to obtain trifluoromethylaryl.

REFERENCES:
patent: 3692843 (1972-09-01), Resnick
patent: 4808748 (1989-02-01), Lin et al.
patent: 4814480 (1989-03-01), Davidson
patent: 4814482 (1989-03-01), Davidson
patent: 4822904 (1989-04-01), Davidson
Qing-Yun Chen and Jian-Xing Duan, A Novel Trifluoromethylation Method of Saturated Organic Halides, Tetrahedron Letters, vol. 34, No. 26, pp. 4241-4244, 1993.
V. V. Berenblit et al., Polyfluoroacyl Fluorides Formed in the Electrochemical Fluorination of Methyl 3-Methoxypropionate, Zhurnal Organicheskoi Khimii, vol. 15, No. 2, pp. 284-292, Feb. 1979.
L. M. D'yachishina et al., Synthesis of Perfluoroalkyl Perfluorovinyl Ethers with Substituents in the Alkyl Group, Zhurnal Organicheskoi Khimii, vol. 8, No. 9, pp. 1790-1793, Sep. 1972.

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