Trifluoromethyl substituted analogs of quinine and quinidine

Details Trifluoromethyl substituted analogs of quinine and quinidine Trifluoromethyl substituted analogs of quinine and quinidine

1974-11-11

1976-04-27

Gallagher, R. J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283R, 260288E, 424259, C07D45304

Patent

active

039534537

ABSTRACT:
Trifluoromethyl substituted analogs of quinine and quinidine are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl-(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde or the corresponding quinuclidine-2 .xi.-carboxylic acid alkyl ester. The end products are useful as antimalarial agents.

REFERENCES:
patent: 3663552 (1972-05-01), Yardley et al.
patent: 3772302 (1973-11-01), Gutzwiller et al.
patent: 3857846 (1974-12-01), Gutzwiller et al.

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