Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind

Details Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]ind

1988-08-19

1990-10-02

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491052

Patent

active

049609025

ABSTRACT:
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for their preparation and use, are disclosed. The derivatives are useful anti-inflammatory and analgesic agents.

REFERENCES:
patent: 3939178 (1976-02-01), Demerson et al.
patent: 4076831 (1978-02-01), Demerson et al.
patent: 4810699 (1989-03-01), Sabatucci et al.
W. A. Sheppard, J. Am. Chem. Soc., 85, 1314-1318 (1963).
P. N. Craig, J. Med. Chem., 14, 680-684 (1971).
W. A. Sheppard, J. Am. Chem. Soc., 83, 4860-4861 (1961).

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