Trifluoro acetyl-cyano-aniline intermediates for dopamine-.beta.

Details Trifluoro acetyl-cyano-aniline intermediates for dopamine-.beta. Trifluoro acetyl-cyano-aniline intermediates for dopamine-.beta.

1987-10-08

1989-10-10

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

564 27, 564214, C07C12200, C07C15707, C07C10334

Patent

active

048733571

ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula: ##STR1## which are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.

REFERENCES:
patent: 4707296 (1987-11-01), Sugimori et al.
Grivsky et al., Ind. Chim. Belg. 39:490-500 (1974).

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