Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-11-07
1999-09-14
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 514327, 514328, 514432, 546208, 546214, 546243, 549 13, 549 78, 549417, 549423, 549428, A61K 3135, A61K 3138, A61K 31445, C07D30910
Patent
active
059523760
ABSTRACT:
Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.
REFERENCES:
patent: 5328929 (1994-07-01), Pettit et al.
patent: 5393897 (1995-02-01), Pettit et al.
patent: 5436400 (1995-07-01), Pettit et al.
Evans DA et al. Tetrahedron Letters. 39(13), 1709-1712, 1998.
Akiyama et al., "Total Synthesis and Absolute Configuration of (-)--Sedacryptine", Synlett, 1996, 100-102.
Bai, R. et al., "The Spongistatins, Potently Cytotoxic Inhibitors of Tubulin Polymerization, Bind in a Distinct Region of the Vinca Domain", Biochem., 1995, 34 , 9714-9721.
Claffey, M.M. et al., "A Method for Constructing the C2-C12 Dispiroacetal Moiety of Altohyrtin A", J. Org. Chem., 1996, 61, 7646-7647.
Dale, J.A. et al., "Nuclear Magnetic Resonance Enantiomer Reagents. Configurational Correlations via Nuclear Magnetic Resonance Chemical Shifts of Diastereomeric Mandelate, 0-Methylmandelate, and .alpha.-Methloxy-.alpha.-Trifluoromethyphenylacetate (MTPA) Esters.sup.1,2 "J. Am. Chem. Soc., 1973, 95, 512-519.
De Lima, C. et al., "Reaction of .alpha.-Sulfonyl Carbanions with Electrophilic Monohalogenocarbenoids: A New Wittig-Like Formation of Alkenes", Synlett, 1992, 133-134.
Dess, D.B. et al., "Readily Accessible 12-I-5.sup.1 Oxidant for the Conversion of Primary and Secondary Alcohols to Aldehydes and Ketones", J. Org. Chem., 1993, 48, 4155-4156.
Fusetani, N. et al., "Cinachyrolide A: A Potent Cytotoxic Macrolide Possessing Two Spiro Ketals from Marine Sponge Cinachyra sp..sup.1 ", J. Am. Chem. Soc., 1993, 115, 3977-3981.
Hayes, C.J. et al., "A Method for Constructing the C18-C28 Dispiroacetal Moiety of Altohyrtin A", J. Org. Chem., 1997, 62, 2678-2679.
Hosokawa, S. et al., "Partial Synthesis of Ciguatoxin, an A/B/C Fragment", Synlett, 1996, 351-352.
Ireland, R.E. et al., "An Improved Procedure for the Preparation of the Dess-Martin Periodinane", J. Org. Chem., 1993, 58, 2889.
Kobayashi, M. et al., "Absolute Stereostructures of Altohyrtin A and Its Congeners, Potent Cytotoxic Macrolides from the Okinawan Marine Sponge Hyrtios altum", Tetra. Lett., 1994, 35(8), 1243-1246.
Kobayashi, M. et al., "Altohyrtin A, a Potent Anti-tumor Macrolide from the Okinawan Marine Sponge Hyrtios altum", Tetrahedron Lett., 1993, 34 (17), 2795-2798.
Kobayashi, M. et al., "Marine Natural Products. XXXVIII. .sup.1) Absolute Stereostructures of Altohyrtins A, B, and C and 5-Desacetylaltohyrtin A, Potent Cytotoxic Macrolides, from the Okinawan Marine Sponge Hyrtios altum", Chem. Pharm. Bull., 1996, 44 (11), 2142-2149.
Paquette, L.A. et al., "A Modular Approach to Marine Macrolide Construction. 1. An Enantiocontrolled Route to the C1-C12 (AB) Spiroacetal Sector", Tetra. Lett., 1996, 38(29), 5115-5118.
Paquette, L.A. et al., "A Modular Approach to Marine Macrolide Construction. 2. Concise Stereocontrolled Synthesis of the C17-C28 (CD) Spiroacetal Component", Tetra. Lett., 1997, 38 (29), 5119-5122.
Paterson, I. et al., "Studies in Marine Macrolide Synthesis: Stereocontrolled Synthesis of the AB-Spiroacetal Subunit of Spongistatin 1 (Altohyrtin A)", Tetra. Lett., 1996, 37(47), 8581-8584.
Paterson, I. et al., "Studies in Marine Macrolide Synthesis: Stereocontrolled Synthesis of the F-Ring Subunit of Spongistatin 1 (Altohyrtin A)", Tetra. Lett., 1997, 38(32), 5727-5730.
Pettit, G.R. et al., "Isolation and Structure of Spongistatin 1.sup.1a ", J. Org. Chem., 1993, 58, 1302-1304.
Pettit, G.R. "Marine animal and terrestrial plant anticancer constituents.sup.a ", Pure & Appl. Chem., 1994, 66(10/11), 2271-2281.
Pornet, J., "Action Du Propargyltrimethylsilane Sure Les Derives Carbonyles En Presence De Tetrachlorure De Titane: Nouvelle Voie D'Acces Aux Derives Chloropreniques", Tetrahedron Lett., 1981, 22, 253-254 (Summary in English).
Lin Qiyan
Smith, III Amos B.
Huang Evelyn Mei
The Trustees of the University of Pennsylvania
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