Tricyclic triazolo derivatives, processes for producing the same

Details Tricyclic triazolo derivatives, processes for producing the same Tricyclic triazolo derivatives, processes for producing the same

1995-05-02

1997-11-04

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514250, 540499, 540506, 540558, 540575, 544354, 544346, 544370, 546192, 546194, 546199, 546214, 546225, 546232, 546241, 5482624, 5483064, 5483101, 560 22, 564441, 564442, A61K 31495, C07D51900, C07D48704, C07D24312

Patent

active

056839987

ABSTRACT:
Novel tricyclic triazolo derivatives and pharmaceutically acceptable salts thereof, which are useful as anti-inflammation agents, anti-allergy agents or anti-PAF agents as well as processes for producing the same are disclosed. The triazolo derivatives of the present invention are represented by the formula (I): ##STR1## cycloalkyl; R.sup.2 and R.sup.3 respectively represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 respectively represents hydrogen or lower alkyl); A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene which may contain one or more hetero atoms; l represents 0 to 2, n represents 1 to 3, . . . represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 (wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.2 respectively represent hydrogen or substituted or non-substituted aryl), CAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above), O--CHAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above) or condensed aromatic ring!.

REFERENCES:
patent: 4464373 (1984-08-01), Barnes
patent: 4668678 (1987-05-01), Brown et al.
patent: 5116841 (1992-05-01), Watjen
Derwent Abstract for JP2-256681 (1990).

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