Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-12-08
1991-02-19
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540543, 540575, 540596, 544359, 544366, 544370, 544375, 544380, 546 16, 546196, 546202, 546203, 546204, 548409, 548525, 548527, A61K 31495, C07D40512
Patent
active
049944630
ABSTRACT:
Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
REFERENCES:
patent: 3354155 (1967-11-01), Tretter
patent: 3420851 (1969-01-01), Bloom et al.
patent: 4282365 (1981-08-01), Rokach et al.
patent: 4585788 (1986-04-01), Helsley et al.
patent: 4596809 (1988-06-01), Takizawa et al.
patent: 4749703 (1988-06-01), Uso et al.
Chem. Abs. vol. 72, 308 (1970), Abstract No. 3387d.
Chem. Abs. vol. 81, 424 (1974), Abstract No. 25566z.
Eur. J. Med. Chem.--Chimica Therapeutica, P. Dostert et al., "Composes Tricycliques Portant une Chaine Alkylaminoalkylthio. Synthese et Activite Pharmacologique," May-Jun. 1974-9, No. 3, p. 259.
J. Med. Chem., M. Cerelli et al., "Antiinflammatory and Aldose Reductase Inhibitory Activity of Some Tricyclic Arylacetic Acids," vol. 29, 2347, (1986).
Arz.--Forcsh., 13, 1039, (1963).
Arz.--Forcsh., 14, 100, (1964).
J. Med. Chem. 19, 941, (1976).
J. Med. Chem. 20, 1499, (1977).
J. Med. Chem. 21, 633, (1978).
Drugs, 13, 161, (1977).
Ishii Akio
Ishii Hidee
Karasawa Akira
Kubo Kazuhiro
Miki Ichiro
Hollrah Glennon H.
Kyowa Hakko Kogyo Co. Ltd.
Turnipseed James H.
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