Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-04-24
2007-04-24
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S071000, C544S101000, C544S344000, C514S250000
Reexamination Certificate
active
10677551
ABSTRACT:
The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens
REFERENCES:
patent: 5011860 (1991-04-01), Blythin et al.
patent: 5847149 (1998-12-01), Fuss et al.
patent: WO 2002/34753 (2002-05-01), None
patent: WO 2003/091252 (2003-11-01), None
H.-J. Boehm, et al., J. Med. Chem., (2000), 43, 2664-2674.
D. K. Chen, et al., N. Engl. J. Med., (1999), 341(4), 233-239.
I. Chopra et al., JAMA, (1996), 275(5), 401-403.
Database Chemcats Online, Chemical Abstracts Service, May 2003, XP002266425.
U. Gerlach, “Synthesis of Tricyclic Cyano-Substituted Tetrahydroquinolines by Radical Decyanation of Geminal Dinitriles”, Tetrahedron Letters, 36(29), (1995), 5159-5162, XP004027630.
D. M. Gleave et al: “Synthesis and Antibacterial activity of [6,5,5] and [6,6,5] Tricyclic Fused Oxazolidinones”, Bioorganic & Medicinal Chemistry Letters, 8(10), May 1998. 1231-1236, XP004137053.
O. K. Kim, et al., Exp. Opin. Ther. Patents (1998), 8(8), 959-969.
P. Kotilainen, et al., J. Infect. Dis., (1990), 161, 41-44.
A. Maxwell, Trends in Microbiology, (1997), 5(3), 102-109.
A. Maxwell, Mol. Microbiol., (1993), 9(4), 681-686.
W. H. N. Nijhuis et al: “A Novel two-step Synthesis of Hexahydropyrazino [1,2-Alphau]-quinolines”, Synthesis, vol. 7, (1987), 641-645, XP002266422.
Walter H. N. Nijhuis, et al: “Stereochemical Aspects of the tert-Amino effect”, J. Org. Chem., 54(1), 1989, 209-16, XP002266423.
L.L. Silver and A. K. Bostian, Antimicrob. Agents and Chemother., Mar. 1993, 37(3), 377-383.
M. Trucksis, et al., Ann. Intern. Med. (1991), 114(5), 424-426.
Willem Verboom, et al: “tert-Amino effect in Heterocyclic Synthesis”, Journal of Organic Chemistry, (1984), 49(2), 269-276, XP002266421.
L.C. Groenen, et al., “The tertiary amino effect in heterocyclic synthesis: Mechanistic and computational study of the formation of six-membered rings” Tetrahedron 1988:44(14);4637-4644.
W.H.N Nijhuis, et al., “The tert-amino effect in heterocyclic chemistry: synthesis of tetra- and pentacyclic compounds” Recl. Trav. Chim. Pays-Bas 1989:108, 172-178.
V. Ojea, et al., “Synthesis of New Heterotricyclic Compounds Containing the [1,8]Naphthyridine Group by Thermal Isomerization of 2-Dialkylamino-3-vinylpyridines” Synthesis 1991:798-802.
V. Ojea, et al., “Formation of New Heterotetracyclic Compounds by Ring Closure of 2-Amino-3-vinylpyridines” Synthesis 1992:152-157.
PCT International Search Report: PCT/IB 03/04389.
H.C. Richards “Oxamniquine: A Drug for the Tropics”, in “The Role of Organic Chemistry in Drug Research” 1985:271-289.
A. Schwartz, et al., “Applications of tert-amino effect and a nitrone-olefin 1,3-dipolar cycloaddition reaction: synthesis of novel angularly annelated diazino heterocycles” Journal of Molecular Structure (Theochem) 2000:528;49-57.
Beke, Gyula, et al., “Syntheis and Stereochemistry of Dispiro Substituted Pyridazines: Application of Ellipticity-Absorbance Ratio Spectra for Proving Enantiomeric Relationship by HPLC-CD/UV Detection”, Chirality, 2002, vol. 14, pp. 365-371.
Csizmadia, Imre G., Journal of Molecular Structure (Theochem), 666, 2003, xii-xiv.
D'yachenko, E. V., et al., “tert-Amino effect in heterocyclic chemistry. Synthesis of hydrogenated spiro derivatives of quinolines”, Russian Chemical Bulletin, International Edition, Jun. 2004, vol. 53, No. 6, pp 1240-1247.
Glukhareva, T. V., et al., “Synthesis of Spiro Derivatives of Pyrrolo[1,2-a]Quinoline”, Chemistry of Heterocyclic Compounds, 2002, vol. 38, No. 11, pp. 1426-1427.
Karolyhazy, Laszlo, et al., “Thermochemical study on the ring closure reaction of 5-morpholino-4-vinylpyridazinones by tert-amino effect”, Journal of Molecular Structure (Theochem), 2003, 666-667, pp. 667-680.
CAS Registry No. 728036-02-0 (1 Record).
CAS Registry No. 727671-74-1 (1 Record).
CAS Registry No. 727371-95-1 (2 Records).
CAS Registry No. 727370-63-0 (1 Record).
CAS Registry No. 704878-08-0 (3 Records).
CAS Registry No. 704878-02-4 (2 Records).
CAS Registry No. 696658-91-0 (2 Records).
CAS Registry No. 696630-59-8 (3 Records).
CAS Registry No. 695220-71-4 (2 Records).
CAS Registry No. 695211-59-7 (4 Records).
CAS Registry No. 695211-58-6 (4 Records).
CAS Registry No. 695202-34-7 (4 Records).
CAS Registry No. 663946-83-6 (1 Record).
CAS Registry No. 401608-21-7 (1 Record).
CAS Registry No. 346630-58-8 (1 Record).
CAS Registry No. 296244-43-4 (7 Records).
Declaration of Alexander R. Hurd, including Exhibits I and II.
Tiwari, et al 5-Nitro-4(2)-[Oxo-3H-Quinazolin-3-yl]-benzyideue-mailonylureas as Antibacterial Agents, J. Indian Chem Soc, 1980, pp. 1039-1040, vol. 57/100.
Barbachyn Michael Robert
Bundy Gordan L.
Dobrowolski Paul Joseph
Hurd Alexander Ross
Martin Gary E.
Ashbrook Charles W.
Baude Eric J.
Habte Kahsay
Pharmacia & Upjohn Company LLC
Young Robert N.
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