Tricyclic tetrahydro naphthaleneols and related compounds

Details Tricyclic tetrahydro naphthaleneols and related compounds Tricyclic tetrahydro naphthaleneols and related compounds

1972-07-03

1978-04-04

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268H, 26029355, 260307A, 2603268, 260327M, 2603402, 424282, 544 58, 544 60, 544 59, 544137, 544148, 544145, 544 79, 544 80, C07D31746, A61L 100

Patent

active

040827739

ABSTRACT:
Compounds are provided of the structure ##STR1## WHEREIN X--Z--Y together with two carbons of the cycloalkyl ring form a 5- or 6-membered ring, wherein R.sup.1 is hydrogen, aralkyl or acyl, n is 0, 1 or 2, and n' is 0, 1, 2 or 3, R.sup.2 is hydrogen, lower alkyl or aralkyl, R.sup.3 is hydrogen, acyl, lower alkyl, aralkyl, lower alkoxy, carboxy, halo, alkenyl, nitro, cycloalkyl, amino, acylamino, R.sup.2 O(CH.sub.2).sub.n 2 where n.sup.2 is 0, 1 or 2 or dihydroxyalkyl, X and Y may be the same or different and can be --CH.sub.2 --, .dbd.N--, --O--, --S--, --NR.sup.4 --, --O--CH.sub.2 --, --S--CH.sub.2 --, or --NR.sup.4 --CH.sub.2 -- where R.sup.4 is hydrogen, lower alkyl or aryl, Z can be ##STR2## where R.sup.5 and R.sup.6 can be hydrogen, lower alkyl, cycloalkyl, aryl, haloalkyl, amino or substituted or unsubstituted aminoalkyl; ##STR3## and --X--Z--Y-- can be taken together to form ##STR4## and ##STR5## These compounds are useful as anti-fibrillatory agents, disinfectants and water-softeners.

REFERENCES:
lucas, Organic Chemistry, 2nd Ed., 1953, Amer. Book Co., N.Y., pp. 460-463.
March, Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, McGraw Hill, 1968, pp. 122-124.

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