Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1997-12-17
2000-01-25
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
549510, 549511, C07C27110, C07D30514
Patent
active
060180730
ABSTRACT:
Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.
REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254703 (1993-10-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5274124 (1993-12-01), Holton
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5290957 (1994-03-01), Correa et al.
patent: 5292921 (1994-03-01), Correa et al.
patent: 5294637 (1994-03-01), Chen et al.
patent: 5336785 (1994-08-01), Holton et al.
patent: 5338872 (1994-08-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5352806 (1994-10-01), Gunawardana et al.
patent: 5380751 (1995-01-01), Chen et al.
patent: 5384399 (1995-01-01), Holton
patent: 5399726 (1995-03-01), Holton et al.
patent: 5405972 (1995-04-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5440056 (1995-08-01), Klein et al.
patent: 5466834 (1995-11-01), Holton
patent: 5478854 (1995-12-01), Farina et al.
patent: 5489601 (1996-02-01), Holton et al.
patent: 5530020 (1996-06-01), Gunawardana et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
patent: 5594157 (1997-01-01), Gunawardana et al.
patent: 5614645 (1997-03-01), Kingston et al.
patent: 5616740 (1997-04-01), Klein et al.
Holton et al., "A Synthesis of Taxusin", J. Am. Chem. Soc., vol. 110, pp. 6558-6560 (1988).
Samaranayake et al., "Modified Taxols. 5.1 Reaction of Taxol With Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity", J. Org. Chem., vol. 56, No. 17, pp. 5114-5119 (1991).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia", JACS 93:9, pp. 2325-2327 (May 5, 1971).
Holton, "Synthesis of the Taxane Ring System", JACS, vol. 106, pp. 5731-5732 (1984).
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron, vol. 34, Report No. 52, pp. 1731-1767 (1978).
Science/Technology, "New Family of Taxol, Taxotere Analogs Developed", Chem. & Engineering News, pp. 26-27 (Apr. 12, 1993).
Senilh et al., "Chime Organique Biologique--Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, Serie II, t. 299, No. 15, pp. 1039-1043 (1984).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side-chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron, vol. 48, No. 34, pp. 6985-7012 (1992).
Denis & Green, "A Highly Efficient, Practical Approach To Natural Taxol", J. Am. Chem. Soc., vol. 110, No. 17, pp. 5917-5919, (1988).
V. Farina et al., "The Chemistry of Taxanes: Unexpected Rearrangement Of Baccatin III During Chemoselective Debenzoylation with Bu.sub.3 SnOMe/LiCl" Tetrahedron Letters, vol. 33, No. 28, pp. 3979-3982 (1992).
D. Kingston et al., "Progress In the Chemistry of Organic Natural Products", Springer-Verlag, New York, pp. 1-206 (1993).
G. Georg et al., "Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-Chlorobenzoyl)-(2'R,2'S)-3'-phenylisoserinate) and Baccatin III 13-(N-Benzoyl-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate)", Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 4, pp. 295-298 (1992).
International Search Report Issued for PCT/US93/10813, dated Mar. 11, 1994.
Chai Ki-byung
Holton Robert A.
Idmoumaz Hamid
Nadizadeh Hossain
Rengan Kasthuri
Florida State University
Trinh Ba K.
LandOfFree
Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substitu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substitu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substitu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2316954