Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substitu

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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549510, 549511, C07C27110, C07D30514

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active

060180730

ABSTRACT:
Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.

REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254703 (1993-10-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5274124 (1993-12-01), Holton
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5290957 (1994-03-01), Correa et al.
patent: 5292921 (1994-03-01), Correa et al.
patent: 5294637 (1994-03-01), Chen et al.
patent: 5336785 (1994-08-01), Holton et al.
patent: 5338872 (1994-08-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5352806 (1994-10-01), Gunawardana et al.
patent: 5380751 (1995-01-01), Chen et al.
patent: 5384399 (1995-01-01), Holton
patent: 5399726 (1995-03-01), Holton et al.
patent: 5405972 (1995-04-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5440056 (1995-08-01), Klein et al.
patent: 5466834 (1995-11-01), Holton
patent: 5478854 (1995-12-01), Farina et al.
patent: 5489601 (1996-02-01), Holton et al.
patent: 5530020 (1996-06-01), Gunawardana et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
patent: 5594157 (1997-01-01), Gunawardana et al.
patent: 5614645 (1997-03-01), Kingston et al.
patent: 5616740 (1997-04-01), Klein et al.
Holton et al., "A Synthesis of Taxusin", J. Am. Chem. Soc., vol. 110, pp. 6558-6560 (1988).
Samaranayake et al., "Modified Taxols. 5.1 Reaction of Taxol With Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity", J. Org. Chem., vol. 56, No. 17, pp. 5114-5119 (1991).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia", JACS 93:9, pp. 2325-2327 (May 5, 1971).
Holton, "Synthesis of the Taxane Ring System", JACS, vol. 106, pp. 5731-5732 (1984).
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron, vol. 34, Report No. 52, pp. 1731-1767 (1978).
Science/Technology, "New Family of Taxol, Taxotere Analogs Developed", Chem. & Engineering News, pp. 26-27 (Apr. 12, 1993).
Senilh et al., "Chime Organique Biologique--Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, Serie II, t. 299, No. 15, pp. 1039-1043 (1984).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side-chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron, vol. 48, No. 34, pp. 6985-7012 (1992).
Denis & Green, "A Highly Efficient, Practical Approach To Natural Taxol", J. Am. Chem. Soc., vol. 110, No. 17, pp. 5917-5919, (1988).
V. Farina et al., "The Chemistry of Taxanes: Unexpected Rearrangement Of Baccatin III During Chemoselective Debenzoylation with Bu.sub.3 SnOMe/LiCl" Tetrahedron Letters, vol. 33, No. 28, pp. 3979-3982 (1992).
D. Kingston et al., "Progress In the Chemistry of Organic Natural Products", Springer-Verlag, New York, pp. 1-206 (1993).
G. Georg et al., "Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-Chlorobenzoyl)-(2'R,2'S)-3'-phenylisoserinate) and Baccatin III 13-(N-Benzoyl-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate)", Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 4, pp. 295-298 (1992).
International Search Report Issued for PCT/US93/10813, dated Mar. 11, 1994.

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