Tricyclic taxanes having a butenyl substituted side-chain and ph

Details Tricyclic taxanes having a butenyl substituted side-chain and ph Tricyclic taxanes having a butenyl substituted side-chain and ph

1997-12-12

1999-12-21

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549510, 549511, C07C27110, C07D30514

Patent

active

060051388

ABSTRACT:
Taxane derivatives having a 3' butenyl substituted C13 side chain.

REFERENCES:
Holton et al., "A Synthesis of Taxusin", J. Am. Chem. Soc., 1988, 110, pp. 6558-6560.
Samaranayake et al., "Modified Taxols. 5.1 Reaction of Taxol With Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity", J. Org. Chem., vol. 56, No. 17, pp. 5114-5119 (1991).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia", JACS 93:9, pp. 2325-2327 (May 5, 1971).
Holton, "Synthesis of the Taxane Ring System", JACS, vol. 106, pp. 5731-5732 (1984).
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron, vol. 34, Report No. 52, pp. 1731-1767 (1978).
Science/Technology, "New Family of Taxol, Taxotere Analogs Developed", Chem. & Engineering News, pp. 26-27 (Apr. 12, 1993).
M. Schulz et al., "Synthesis of New N-radicals of Tetrazanl-yl", Chem. Abstr., vol. 108, No. 37298C, pp. 581 (1988).
Senilh et al., "Chime Organique Biologique--Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, t. 299, Serie II, No. 15, pp. 1039-1043 (1984).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side-chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron, vol. 48, No. 34, pp. 6985-7012 (1992).
Denis & Green, "A Highly Efficient, Practical Approach To Natural Taxol", J. Am. Chem. Soc., vol. 110, No. 17, pp. 5917-5919, (1988).
Witherup et al., "High Performance Liquid Chromatographic Separation of Taxol and Related Compounds From Taxus Brevifolia", Jour. of Liquid Chromatography, 12(11), pp. 2117-2132 (1989).
Kaiser et al., "Synthesis of Esters of Acid-Unstable Alcohols by Means of n-butyllithium", J. Org. Chem., vol. 35, p. 1198, (1970).
Bartholomew et al., "A Novel Rearrangement Reaction Conversion of 3-(chloromethyl) azetidin-2-ones to Azetidine-3-carboxylic Acid Esters", Tetrahedron Letters, vol. 32, No. 36, pp. 4795-4798, (1991).
N.F. Magri et al., "Modified Taxols, 4. Synthesis and Biological Activity of Taxols Modified in the Side-Chain", Journal of Natural Products, vol. 51, No. 2, pp. 298-306 (1988).
H.M. Deutsch et al., "Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol with Potent Antitumor Activity", Journal of Medicinal Chem., vol. 32, No. 4, pp. 788-792, (Apr. 1989).
International Search Report Issued for PCT/US93/10813, dated Mar. 11, 1994.

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