Tricyclic steroid analogs

Details Tricyclic steroid analogs Tricyclic steroid analogs

1991-12-20

1993-04-27

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

568373, 568817, 564459, 558429, 560256, 562499, C07C 69608

Patent

active

052064158

ABSTRACT:
Novel tricyclic steriod analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: ##STR1## wherein R.sub.1 =H or C.sub.1 -C.sub.4 alkyl or fluoroalkyl;

REFERENCES:
patent: 2830075 (1958-04-01), Farinacci
patent: 3499913 (1970-03-01), Joly et al.
patent: 3676461 (1972-07-01), Muller et al.
patent: 3821288 (1974-06-01), Crabbe et al.
patent: 4874891 (1989-10-01), Covey et al.
Phillipps et al., in Molecular Mechanisms in General Anesthesia, Eds. Halsey et al., Churchill Livingston, N.Y. 1974, pp. 32-47.
Majewska, Biochem. Pharmacal. 36, 3781-3788 (1987).
Metcalf et al., TIPS 10, 491-495 (1989).
The Merck Index, 11th ed., 1989, No. 6280.
Villotti et al., J. Am. Chem. Soc., 82, 5693-5700 (1960).
Capsi & Balasubrahanyam, Tetrahedron Lett. 12, 745-748 (1963).
Cross et al., J. Med. Chem. 6, 162-166 (1963).

Affiliated with

Also associated with

Rating

Tricyclic steroid analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic steroid analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic steroid analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2328727