Tricyclic quinoline antineoplastic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514212, 5142285, 5142328, 514254, 514287, 514293, 514322, 540575, 540596, 540597, 540599, 544 581, 544 586, 544 60, 544 61, 544125, 544126, 544361, 546 64, 546 83, 546199, A61K 31495, A61K 3154, A61K 31535, A61K 3155

Patent

active

050718487

ABSTRACT:
Isothiazolo-quinoline derivatives are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases.

REFERENCES:
patent: 4767762 (1988-08-01), Chu
patent: 4880814 (1989-11-01), Chu et al.
R. B. Lock et al., Anti Cancer Drug Design (1987), 2, 151-164.
Peter D'Arpa et al., Biochimica et Biophysica Acta. 989 (1989) 163-177.
Lui, Annu. Rev. Biochem. 1989, 58-351-75.
Phillips et al., Drug Reviews, Clinical Pharmacy, vol. 2, 1983, pp. 112-119.

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