Tricyclic pyrazole kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S358000, C544S359000, C544S366000, C544S371000, C548S356100, C548S358100, C548S359100, C514S252120, C514S254010, C514S403000, C514S406000

Reexamination Certificate

active

07468371

ABSTRACT:
Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

REFERENCES:
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patent: 6297238 (2001-10-01), Doyle et al.
patent: 6407103 (2002-06-01), Doyle et al.
patent: 6462036 (2002-10-01), Doyle et al.
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patent: 03/033499 (2003-04-01), None
patent: 03/070236 (2003-08-01), None
Nugiel et al., “Indenopyrazoles as Novel Cyclin Dependent Kinase (CDK) Inhibitors,” J. Med. Chem. 44:1334-1336 (2001).
Nugiel et al., “Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substitutent Pattern,” J. Med. Chem. 46:5224-5232 (2002).
Yue et al., “Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships as C31,2,” J. Med. Chem. 45:5233-5248 (2002).

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