Tricyclic pteridinones and a process for their preparation

Details Tricyclic pteridinones and a process for their preparation Tricyclic pteridinones and a process for their preparation

1992-10-16

1998-12-29

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 60, 544251, 5442282, 5442332, 544250, C07D48714, A61K 31505

Patent

active

058544194

ABSTRACT:
This invention relates to novel tricyclic pteridinones, their aza analogs and their pharmaceutically acceptable salts. Further encompassed by the invention is a novel process for the production of the tricyclic pteridinones and their aza analogs. The compounds of the invention exhibit cardiovascular properties, particularly mixed vasodilation and selective venous and arterial dilation. Pharmaceutical compositions are proposed for the compounds.

REFERENCES:
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patent: 4440929 (1984-04-01), Lee et al.
patent: 4446323 (1984-05-01), Freed et al.
patent: 4696928 (1987-09-01), Ellames et al.
patent: 4968682 (1990-11-01), Hansen et al.
patent: 5055465 (1991-10-01), Davey
Parthasarathy et al., CA 101:55037b (1984).
Gakhar et al., CA 101:191852r (1984).

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