Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-09-13
1985-04-09
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
2602433, 544115, 544346, 546276, 548262, C07D48704, C07D47114, A61K 3150, A61K 31535
Patent
active
045101418
ABSTRACT:
The invention relates to novel polycyclic polyazaheterocycles having psychopharmacological properties, especially antidepressive and anxiolytic activity, corresponding to the formula I ##STR1## in which R.sub.1 and R.sub.2 each represents, independently of the other, hydrogen, lower alkyl or hydroxy-lower alkyl, or together represent lower alkylene or ethyleneoxyethylene, ethyleneazaethylene or N-lower alkyl- or N-(2-hydroxy-lower alkyl)-ethyleneazaethylene, R.sub.3 represents hydrogen or a lower aliphatic hydrocarbon radical or a saturated lower cycloaliphatic hydrocarbon radical or unsubstituted or substituted phenyl, R.sub.4 and R.sub.5 represent hydrogen or lower alkyl, and Ar represents an unsubstituted or substituted benzo or pyrido radical, and to acid addition salts of compounds of the general formula I, especially the pharmaceutically acceptable acid addition salts of compounds of the general formula I, to pharmaceutical preparations containing these novel substances and to a method of treating conditions of depression or anxiety by administering them.
REFERENCES:
patent: 3878205 (1975-04-01), Gagneux et al.
patent: 4235775 (1980-11-01), Meguro et al.
Yurugi et al., Chem. Abstracts, vol. 80, item 37073d, (1974).
Maki et al., Chem. Abstracts, vol. 81, item 152214h, (1974).
Hester et al., J. Med. Chem., vol. 23, pp. 392-402, (1980).
Berch Mark L.
Ciba-Geigy Corporation
Glynn Michael W.
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