Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-09-11
1999-10-12
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514225, 544361, 546 93, A61K 3144, C07D22106
Patent
active
059655704
ABSTRACT:
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Baldwin John J.
Cooper Alan B.
Doll Ronald J.
Girijavallabhan Viyyoor M.
Mallams Alan K.
Majka Joseph T.
McKane Joseph K.
Pharmacopeia Inc.
Schering Corporation
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