Tricyclic or tetracyclic carbapenem compounds, their production

Details Tricyclic or tetracyclic carbapenem compounds, their production Tricyclic or tetracyclic carbapenem compounds, their production

1993-09-22

1995-10-17

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48714, C07D47114, C07D49114, C07D49514, C07D49714, A61K 3140

Patent

active

054592607

ABSTRACT:
A polycyclic carbapenem compound of the formula (Ia'), (Ib') or (Ic') ##STR1## [wherein COOR.sup.2 is a carboxy group which may be esterified; R.sup.a' is --(CH.sub.2).sub.m --K.sup.a --(CH.sub.2).sub.n --U.sup.a' ; J is O or S; R.sup.b' is --(CH.sub.2).sub.m --K.sup.b --(CH.sub.2).sub.n U.sup.b' ; J' is O, S or CH.sub.2 ; R.sup.c' is --(CH.sub.2).sub.m --K.sup.c --(CH.sub.2).sub.n --U.sup.c', --(CH.sub.2).sub.m --K.sup.d --(CH.sub.2).sub.n --U.sup.d or a pair of groups, one of which is a hydroxy group, with the other being a hydroxzy group or an alkylsulfonylamino group, which may be substituted, in the position ortho to the first-mentioned hydroxy group] or a salt thereof are useful as an antibacterial agent.

REFERENCES:
patent: 4036969 (1977-07-01), Stirling
patent: 4374848 (1983-02-01), Christensen et al.
patent: 4374849 (1983-02-01), Christensen et al.
patent: 4600713 (1986-07-01), Christensen et al.
patent: 5021565 (1991-06-01), Ratcliffe et al.
Tetrahedron Letters, vol. 25, No. 26, 1984, pp. 2793-2796. Yoshida et al.
Tetrahedron Letters, vol. 22, No. 50, 1981, pp. 5027-5030, Heck et al.

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