Tricyclic nitrogen ring compounds, their production and use

Details Tricyclic nitrogen ring compounds, their production and use Tricyclic nitrogen ring compounds, their production and use

1997-01-14

1999-09-28

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544238, 544333, 546 79, 546 84, 546 93, C07D47104, C07D40106, A61K 3144

Patent

active

059589426

ABSTRACT:
Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

REFERENCES:
Jazwinski et al., Bulletin of the Polish Academy of Sciences Chemistry, 37(7-8), 313-316 (1989).
Stefaniak et al., Journal of Crystallographic and Spectroscopic Research, 19(1), 159-66 (1989).
Kurata et al., "Synthesis of Indolizine Derivatives and Their Reactions. II.sup.1) ", 5(98), 631-635 (1978). (with translation).
Sablji et al., Journal of Molecular Structure, 49(2), 415-420 (1978).
Ceder et al., Journal of Heterocyclic Chemistry, 13(5), 1029-1031 (Oct. 1976).
Paudler et al., The Journal of Heterocyclic Chemistry, 9(1), 81-85 (Feb. 1972).
Rees et al., J. Chem. Soc. Perkin Trans. I, 1159-1163 (1987).
L. Gesualdo et al., "Platelet-derived growth factor and proliferative glomerulonephritis", Kidney International, vol. 43, Suppl. 39, pp. S-86-S-89, (1993).
R. Johnson et al., "Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor", Journal of Experimental Medicine, vol. 175, pp. 1413-1416, (May 1992).

Affiliated with

Also associated with

Rating

Tricyclic nitrogen ring compounds, their production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic nitrogen ring compounds, their production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic nitrogen ring compounds, their production and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-703664