Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-05-10
1990-11-27
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540521, 540522, 540523, C07D51304, A61K 3155
Patent
active
049735853
ABSTRACT:
This invention relates to derivatives of fused bicyclic or tricyclic lactams, to the intermediates and processes useful for their preparation and to their pharmacological effect in inhibiting the angiotensin converting enzyme and to their end-use application in the treatment of hypertension.
REFERENCES:
patent: 4584294 (1986-04-01), Ruyle
P. R. Andrews et al., "Conformational Analysis and Active Site Moddeling of Angiotensin-Converting Enzyme Inhibitors", J. Med. Chem., 28, 393-399, 1985.
Beight Douglas W.
Flynn Gary A.
Bond Robert T.
Merrell Dow Pharmaceuticals
Stein William J.
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