Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1981-02-19
1983-12-27
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548431, C07D20946
Patent
active
044232322
ABSTRACT:
Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino]2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
Claimed compounds include those of the formula ##STR1## in which R.sup.3 and R.sup.4 each is hydrogen, lower alkoxy, lower alkyl, trifluoromethyl, halo or hydroxy, or R.sup.3 and R.sup.4 together form an OCH.sub.2 O chain; and R.sup.14 and R.sup.15 each is hydrogen or lower alkyl.
REFERENCES:
patent: 3892771 (1975-07-01), Eberle
H. J. Roth et al., Arch. Pharm., 309, 58 (1976).
Derwent Publications Ltd., Farmdoc 21903v for Japanese Patent J4 9014459.
Chem. Abst. 78:58179s (1973) for Tetra. Letters, 4517 (1972).
Chem. Abst. 55:15485c (1961) for Gazz Chim. Ital., 90, 559 (1960).
E. Breuer et al., Tetrahedron, 31, 499 (1975).
F. M. Rowe et al., J. Chem. Soc., 1098 (1936).
Chem. Abst. 94:47112u (1981).
Demerson Christopher A.
Ferland Jean-Marie
Humber Leslie G.
American Home Products Corporation
Daus Donald G.
Eakin M. C.
Wilfond Arthur E.
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