Tricyclic inhibitors of poly(ADP-ribose) polymerases

Details Tricyclic inhibitors of poly(ADP-ribose) polymerases Tricyclic inhibitors of poly(ADP-ribose) polymerases

2008-09-30

2008-09-30

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S220000, C514S411000

Reexamination Certificate

active

11221245

ABSTRACT:
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease.As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

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