Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1997-05-20
1999-09-28
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514290, 514292, 514577, 562466, 560 56, 560 55, 546 85, 546 86, 546 87, 546111, A61K 31215, A61K 3144
Patent
active
059589728
ABSTRACT:
Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.
REFERENCES:
patent: 3649651 (1972-03-01), Dobson
patent: 3728349 (1973-04-01), Dobson et al.
patent: 5326760 (1994-07-01), McElroy et al.
Dygos, J.H., et al., J of Med Chem, 1977, 20:12, 1705-1708.
Campaigne, E., et al., J Hetero Chem, 1969, 6:6, 885-889.
Child, et al., Arzneim-Forsch/Drug Res, 1980, 30(I):4a, 695-702.
International Search Report.
Mather, K C et al CA97:55445 (1981).
CA 55: 10405 a.
Brain, vol. 111, 1988, Miller et al., pp. 927-939.
Neurology, vol. 41, 1991, Barkhof et al., pp. 1219-1222.
Biochemical Pharmacology, vol. 47, No. 10, 1994, Moor et al., pp. 1717-1724.
Nature, vol. 356, 1992, Yednock et al., pp. 63-66.
Brain Research, vol. 576, 1992, Rosenberg et al., pp. 203-207.
J. Cell Biology, vol. 125, No. 5, 1994, Romanic and Madri, pp. 1165-1178.
TiPS Reviews, vol. 14, 1993, Dijkstra et al., pp. 124-129.
Annals of Neurology, vol. 36, 1994, Wekerle et al., pp. S47-S53.
J. Neurochem., vol. 50, No. 3, 1988, Chantry et al., pp. 688-694.
Biochemical and Biophysical Research Communications, vol. 192, No. 3, 1993, Proost et al., pp. 1175-1181.
Journal of Cellular Physiology, vol. 157, 1993, Weeks et al., pp. 644-649.
Biochemica et Biophysica Acta, vol. 1176, 1993, Montgomery et al., pp. 265-268.
Current Opinion in Neurology and Neurosurgery, vol. 5, 1992, Lublin, pp. 182-187.
Journal of Neuroimmunology, vol. 21, 1989, Sternberger et al., pp. 241-248.
Nature, vol. 370, 1994, Mohler et al., pp. 218-220.
Nature, vol. 370, 1994, Gearing et al., pp. 555-557.
The Journal of Immunology, vol. 154, 1995, Verbeek et al., pp. 5876-5884.
Cellular Immunology, vol. 81, 1983, McKenna et al., pp. 391-402.
Cellular Immunology, vol. 112, 1988, Bitar and Whitacre, pp. 364-370.
Journal of Neuroimmunology, vol. 34, 1991, Kuroda and Shimamoto, pp. 159-164.
The Journal of Immunology, vol. 147, No. 7, 1991, Whitacre et al., pp. 2155-2163.
Journal of Neuroimmunology, vol. 38, 1992, O'Neill et al., pp. 53-62.
Journal of Neuroimmunology, vol. 39, 1992, Whitacre et al., pp. 175-182.
Cellular and Molecular Immunology, ed. Saunders, 1991, Abbas et al., pp. 364-369.
Nature, vol. 370, 1994, McGeehan et al., pp. 558-561.
J. Clin. Invest., vol. 94, 1994, Galis et al., pp. 2494-2503.
Proc. Nat'l. Acad. Sci. USA, vol. 88, 1991, Henney et al., pp. 8154-8158.
Clin. Sci., vol. 81, 1991, Vine and Powell, pp. 233-239.
Am. J. Cardiol., vol. 72, 1993, Lee et al., pp. 672-676.
Clin. Res., vol. 41, 1993, Reddy et al., p. 660A.
Clin. Res., vol. 41, 1993, Tyagi et al., p. 681A.
Can. J. Cardiol., vol. 10, 1994, Armstrong et al., pp. 214-220.
Am. J. Physiol., vol. 263, 1992, Sabbah et al., pp. H266-H270.
Circulation Research, vol. 75, 1994, Bendeck et al., pp. 539-545.
Circulation Research, vol. 75, 1994, Pauly et al., pp. 41-54.
J. Periodontal Res., vol. 16, 1981, Uitto et al., pp. 417-424.
J. Periodontal Res., vol. 22, 1987, Overall et al., pp. 81-88.
Arch. Opthalmol., vol. 81, 1969, Brown et al., pp. 370-373.
Invest. Opththamol., vol. 30, 1989, Burns et al., pp. 1569-1575.
Cancer Res., vol. 53, 1993, Davies et al., pp. 2087-2091.
Cancer Res., vol. 52, 1992, Melchiori et al., pp. 2353-2356.
Cancer Res., vol. 52, 1992, DeClerck et al., pp. 701-708.
J. Biol. Chem., vol. 268, No. 19, 1993, Strongin et al., pp. 14033-14039.
Cancer Res., vol. 53, 1993, Monsky et al., pp. 3159-3164.
Journal of the National Cancer Institute, vol. 87, No. 4, 1995, Taraboletti et al., pp. 293-298.
Oncology Research, vol. 6, 1994, Benelli et al., pp. 251-257.
Arthritis and Rheumatism, vol. 35, No. 1, 1992, Walakovits et al., pp. 35-42.
J. Rheumatol., vol. 20, No. 4, 1993, Zafarullah et al., pp. 693-697.
Agents Actions, vol. 37, No. 1/2, 1992, Andrews et al., pp. 147-154.
Biochem. Biophys. Res. Commun., vol. 201, No. 1, 1994, Ellis et al., pp. 94-101.
J. Clin. Invest., vol. 94, 1994, Gijbels et al., pp. 2177-2182.
Scientific American, vol. 269, No. 3, 1993, Steinman, pp. 107-114.
Cell-Immunol., vol. 82, No. 1, 1983, Paterson, pp. 55-74.
Annals of the New York Academy of Sciences, eds Scheinberg and Raine, vol. 436, 1984, Bornstein et al., pp. 366-372.
Bio/technology, vol. 13, 1995, Steinman and Conlon, pp. 118-120.
Immunol-Ser., vol. 59, 1993, Steinman et al., pp. 253-260.
The Blood Brain Barrier in Health and Disease, edited by Suckling et al., 1986, Lam, pp. 158-164.
Hupe Donald
Johnson Linda Lea
Picard Joseph Armand
White Andrew David
Ye Qi-Zhuang
Owens Amelia
Tinney Francis J.
Warner-Lambert & Company
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