Tricyclic hydroxamate and benzamide derivatives,...

Details Tricyclic hydroxamate and benzamide derivatives,... Tricyclic hydroxamate and benzamide derivatives,...

2011-04-12

2011-04-12

Sullivan, Daniel M (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S579000

Reexamination Certificate

active

07923579

ABSTRACT:
The present invention relates to compounds and methods for inhibiting histone deacetylase enzymatic activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit histone deacetylases (IIDACs), and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, and also central nervous system diseases. It further deals with processes for preparing said compounds.

REFERENCES:
patent: 4829080 (1989-05-01), Maignan et al.
patent: 5567721 (1996-10-01), Bernardon et al.
patent: 0 382 076 (1990-08-01), None
patent: 97/33856 (1997-09-01), None
patent: 01/38322 (2001-05-01), None
patent: 01/56358 (2001-08-01), None
patent: 02/22577 (2002-03-01), None
patent: 02/098363 (2002-12-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al. Advanced Drug Delivery Reviews 2001, 48, 3-26, abstract.
International Search Report of PCT/IB2004/004334, mailed Apr. 22, 2005.
Zacheis et al., “Heteroarotinoids Inhibit Head and Neck Cancer Cell Lines in Vitro and in Vivo Through Both RAR and RXR Retinoic Acid Receptors”, Journal of Medicinal Chemistry, 1999, vol. 42, No. 21, pp. 4434-4445, XP002278654.
Lavoie et al., “Design and Synthesis of a Novel Class of Histone Deacetylase Inhibitors”, Bioorganic & Medicinal Chemistry Letters, vol. 11, No. 21, 2001, pp. 2847-2850, XP002954135.

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