Tricyclic heterocycle compound

Details Tricyclic heterocycle compound Tricyclic heterocycle compound

2011-01-18

2011-01-18

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S278000

Reexamination Certificate

active

07872133

ABSTRACT:
The present invention relates to the compound represented by formula (I)in-line-formulae description="In-line Formulae" end="lead"?A-X—Y—Z—B  (I)in-line-formulae description="In-line Formulae" end="tail"?(wherein A is a cyclic group which may have a substituent(s); X is a single bond or a spacer; Y is a single bond or a spacer; Z is a single bond or a spacer; B is a hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s)), a salt thereof, a solvate thereof or a prodrug thereof. The compound represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for preventive and/or therapeutic agent for a disease caused by stress.

REFERENCES:
patent: 3959470 (1976-05-01), Mashkovsky et al.
patent: 4336260 (1982-06-01), Payne et al.
patent: 5095020 (1992-03-01), Hulkenberg et al.
patent: 5403851 (1995-04-01), D'Orlando et al.
patent: 6043252 (2000-03-01), Bombrun
patent: 6048868 (2000-04-01), Fourtillan et al.
patent: 6350757 (2002-02-01), Goldstein et al.
patent: 7368444 (2008-05-01), Seko et al.
patent: 7403851 (2008-07-01), Kaufman et al.
patent: 2002/0010189 (2002-01-01), Sui et al.
patent: 2004/0072833 (2004-04-01), Nakai et al.
patent: 2004/0116458 (2004-06-01), Sawyer et al.
patent: 2004/0122035 (2004-06-01), Orme et al.
patent: 2004/0132735 (2004-07-01), Troxler et al.
patent: 2004/0147542 (2004-07-01), Sawyer et al.
patent: 2004/0152736 (2004-08-01), Chackalamannil et al.
patent: 2008/0114012 (2008-05-01), Ohmoto et al.
patent: 0 740 668 (1998-07-01), None
patent: 1 438 973 (2004-07-01), None
patent: 1475368 (2004-11-01), None
patent: 1 431 702 (1976-04-01), None
patent: 1444980 (1976-08-01), None
patent: 3-287586 (1991-12-01), None
patent: 09-508113 (1997-08-01), None
patent: 9-511246 (1997-11-01), None
patent: 2001-072679 (2001-03-01), None
patent: 2002-517500 (2002-06-01), None
patent: 2002-524564 (2002-08-01), None
patent: 2004-501919 (2004-01-01), None
patent: 2004-518729 (2004-06-01), None
patent: 2004-518730 (2004-06-01), None
patent: 2004-532852 (2004-10-01), None
patent: 95-26723 (1995-10-01), None
patent: 97/43287 (1997-11-01), None
patent: 99-64420 (1999-12-01), None
patent: 00-15639 (2000-03-01), None
patent: 01-87038 (2001-11-01), None
patent: 2004-113300 (2001-12-01), None
patent: 02-00657 (2002-01-01), None
patent: 02-053565 (2002-07-01), None
patent: 02-064590 (2002-08-01), None
patent: 02-064591 (2002-08-01), None
patent: 02-081471 (2002-10-01), None
patent: 02/088123 (2002-11-01), None
patent: 03-068753 (2003-08-01), None
patent: 03/099821 (2003-12-01), None
patent: 2005/070930 (2005-08-01), None
patent: 2005/089764 (2005-09-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker (Modern Pharmaceutics) Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
International Search Report dated Oct. 5, 2004.
Haishan Wang, et al., “Synthesis and Evaluation of Tryprostatin B and Demethoxyfumitremorgin C Analogues”, Journal of Medicinal Chemistry, 2000, vol. 43, No. 8, pp. 1577-1585.
Brian E. Love, et al., “Preparation of 1-Aryl-β-carbolines”, Journal of Organic Chemistry, 1994, vol. 59, No. 11, pp. 3219-3222.
B. Bonaz, Y. Taché, “Water-Avoidance Stress-Induced c-fos Expression In The Rat Brain and Stimulation of Fecal Output: Role of Corticotropin-Releasing Factor”, Brain Research, 624, pp. 21-28 (1994).
Michikazu Abe, Ken-Ichi Saito, “Reduction of Wrap Restraint Stress-Induced Defecation by MKC-242, a Novel Benzodioxan Derivative, via 5-HT 1A-Receptor Agonist Action in Rats”, Jpn. J. Pharmacol. 77, pp. 211-217 (1998).
Cain, M et al., “Beta-Carbolines: Synthesis and Neurochemical and Pharmacological Actions on Brain Benzodiazepine Receptors”, Journal of Medicinal Chemistry, Sep. 1982, pp. 1081-1091, vol. 25, No. 9.
Supplementary European Search Report dated Jul. 29, 2009.
Cain, M et al., “Beta-Carbolines: Synthesis and Neurochemical and Pharmacological Actions on Brain Benzodiazepine Receptors”, Journal of Medicinal Chemistry, Sep. 1982, pp. 1081-1091, vol. 25, No. 9, American Chemical Society, Washington, US.
Limbach, et al.; “Addition of Indole to Methyl 2-Chloro-2-cyclopropylideneacetate en Route to Spirocyclopropanated Analogues of Demethoxyfumiremorgine C and Tadalafil”; Eur. J. Org. Chem., 2005, vol. 3, pp. 610 to 617.
L.N. Yakhontov, et al.; “Azaindol derivatives XXXVIII. Normal and abnormal course of reactions during 12-aza-b-carboline synthesis”; Khimiya Geterotsiklicheskikh Soedinenii, 1970, vol. 11, pp. 1550-1553.
European Search Report Dated Dec. 3, 2009 for Application No. 05820106.2-2101/1829874 (PCT/JP2005/023450).
International Search Report (PCT/ISA/210) for PCT/JP2005/023450, dated Apr. 11, 2006.
Chemical Abstracts Service; C. Balsamini, et al.; “N-benzhydryltryptamines and 1, 1-diphenyltetrandrobeta-carbolines: synthesis, x-ray crystal structure and benzodiazepine receptor affinity” XP002556789; retrieved from STN Database accession No. 1989:526474; ISSN: 0014-827X; 1989; 1 page in total.

Affiliated with

Also associated with

Rating

Tricyclic heterocycle compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic heterocycle compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic heterocycle compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2688771