Tricyclic heteroaryl piperazines, pyrrolidines and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S416000, C548S427000, C548S429000, C548S430000, C514S410000

Reexamination Certificate

active

07423056

ABSTRACT:
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

REFERENCES:
patent: WO 9965911 (1999-12-01), None
patent: WO 2003 051883 (2003-06-01), None
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Siavosh Mahboobi et al. “Carbazole DerivativeS With Antimycobacterial Activity” Archiv der Pharmazie, Weinheim, Germany 1994 vol. 327(10) pp. 611-617.
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David L Coffen et al. “Syntheses Of An Antipsychotic Pyrrolo [2,3-g]isoquinoline From Areca Alkaloids” Journal of Organic Chemistry Nutley, NJ 1984, vol. 49(26) pp. 5109-5113.
Gary L Olson “Dopamine Receptor Model And Its Application In The Design Of A New Class Of Rigid Pyrrolo [2,3-g]isoquinoline Antipsychotics” Journal of Medicinal Chemistry Nutley, NJ 1981, vol. 24(9) pp. 1026-1034.
Lionel Chevolot et al. “Studies In The Indole Series. XII. Synthesis Of Indole Alkaloids And Structural Analogs Via 5, 6-dihydropyridinium Salts” Bulletin de la Societe Chimique de France Gif-suf-Yvette, France 1976, pp. 1222-1226.
L G Rashidyan et al “Isoindoline Derivatives. I. Synthesis Of Some Diamines Of The Isoindoline Series” Armyanskii Khimicheskii Zhurnal Erevan, USSR 1968, vol. 21(9) pp. 793-807.

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