Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-11-09
2010-12-21
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S246000, C514S248000, C514S249000, C514S250000, C514S267000, C514S293000, C544S180000, C544S184000, C544S234000, C544S250000, C544S251000, C544S346000, C546S082000
Reexamination Certificate
active
07855206
ABSTRACT:
The present invention is directed to novel substituted tricyclic heteroaromatic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
REFERENCES:
patent: 2007/0232676 (2007-10-01), Biftu et al.
patent: 2007/0254865 (2007-11-01), Biftu et al.
patent: 2008/0076773 (2008-03-01), Cox et al.
patent: 2009/0105284 (2009-04-01), Biftu et al.
patent: WO2006/009886 (2006-01-01), None
patent: WO2006/039325 (2006-04-01), None
patent: WO2006/039325 (2006-04-01), None
patent: WO 2006/127530 (2006-11-01), None
patent: WO2006/127530 (2006-11-01), None
patent: WO2006/127530 (2006-11-01), None
patent: WO2007/087231 (2007-08-01), None
patent: WO2007/087231 (2007-08-01), None
patent: WO2007/097931 (2007-08-01), None
patent: WO2007/097931 (2007-08-01), None
patent: WO2007/126745 (2007-11-01), None
patent: WO2007/126745 (2007-11-01), None
patent: WO2007/136603 (2007-11-01), None
patent: WO2007/136603 (2007-11-01), None
Aertgeerts, K. et al., “Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation”, Protein Science, 2004, pp. 412-421, vol. 13.
Cox Jason M.
Dong Hong
Fair Janet E.
Leeser Erich A
Merck Sharp & Dohme Corp.
Todaro John C.
Wilson James O
LandOfFree
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